| Insomnia is a very universal problem, which is usually triggered by the anxiety-depression emotion due to the stress events in life. Insomnia is often accompanied with depressive disorder, and it even may be covered by insomnia. In modern medicine, although there are many kinds of sedative hypnotics with quick effects and strong functions, some shortages exist, such as a certain degree of side-effect, potential addiction, expensive prices of parts of drugs, and unstable effects.Objective: This paper observed the effect of the soothing liver and regulating mind acupuncture method in treating patients of insomnia with depressive disorder. Take Trazodone (Mesyrel) as the positive control drug, compare the effect difference of these two methods while treating this disease, and discuss the mechanism of the soothing liver and regulating mind acupuncture in dealing with insomnia.Method: Observed 65 cases of insomnia with depressive disorder that belong to the differentiation of pathogenic fire derived from the stagnation of liver qi, according to the diagnose criteria of CCMD-3 and Diagnose and Effect Standard of Diseases in TCM (1994) issued by State Administration of Traditional Chinese Medicine, and divide into two groups with randomized method. There were 33 cases in acupuncture group used soothing liver and regulating mind needling, and 32 cases in the control drug group (Trazodone). One course is composed of 4 weeks. Use Pittsburg Sleep Quality Index Rating Scale (PSQI), Self-rating Depressive Scale (SDS), and Asberg Side-effect Rating Scale (SERS) to compare the effects. Soothing liver and regulating mind acupuncture group selects Shenmen (both), Baihui, Yintang, Hegu (both), and Taichong (both), and filiform needles with the specification of 0.30mm diameter, and 30mm long were applied. Insert the needle horizontally forward about 15~20mm on Baihui, and use uniform reinforcing-reducing twirling method. Insert the needle perpendicularly about 5~10mm on Shenmen with uniform reinforcing-reducing method. Insert the needle horizontally downward about 5~10mm on Yintang, and use reinforcing-reducing twirling method. Both Hegu and Taichong were vertically pricked about 5~15mm deep, and both of them use reducing method. Apply it once per day, retain the needles for30min, and apply 6 times per week. Take a rest at weekends, and 4 weeks constitute one course. The western medicine group used 50~150mg Trazodone (Mesyrel) for 4 weeks.Result: The comparisons of each item and total score of PSQI of the patients in soothing liver and regulating mind acupuncture group and western drug group before and after treatment have significant differences (P<0.01). The comparison of the total scores of PSQI between groups have no significant difference (P>0.05), while soothing liver and regulating mind acupuncture group is better than those of western medicine group at the aspects of sleep quality and daytime functional assessment, and the scores of the other items of the two groups are proximal (P>0.05). Before and after the treatment, the scores of self-rating depressive scale(SDS) of patients of both groups were obviously lowered (P<0.01), but the comparison of the SDS scores of the patients of the two groups after treatment has no obvious statistical difference (P>0.05). During the treating procedure, besides the fall-off patients, the score of drug group after treatment is significantly higher than that of soothing liver and regulating mind acupuncture group (P <0.05), according to the score of Asberg drug side effect scale.Conclusion: Soothing liver and regulating mind acupuncture method has curative effects on insomnia with depressive disorder, and there is no obvious difference between the total clinical effect of treating group and Trazodone group. The overall evaluations of the clinical sleep quality of these two groups have no apparent difference, while soothing liver and regulating mind acupuncture group is better than those of Trazodone group on sleep quality and daytime functional assessment. The side-effect of soothing liver and regulating mind acupuncture is less than that of western medicine (Trazodone).This study discussed the pathogenesis of insomnia with depressive disorder in TCM. The source of this disease is liver, heart is the place of the progress, and emotional hurt and restlessness are the important etiologies and pathogenesis of this disease. Recuperating under medical treatment from heart and liver is an important idea and method to deal with insomnia with depressive disorder. Meanwhile, it was proved that soothing liver and regulating mind acupuncture has a certain effect of calming and hypnosis, as well as anti-depression, which is applicable to insomnia with depressive disorder, and it is deserved to be wide spread in clinic.
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