A Study On Correlation Between Gene Polymorphism Of Homocysteine And Its Metabolic Key Enzyme In Xinjiang Uygur Ethnic Minority Group And In Han Ethnic Group And Coronary Heart Disease

BackgroudCoronary hear disease (CHD) is progressive chronic disease caused by the synergetic effect of multi-risk-factors and at the present is one of the most serious diseases endangering human health and life. The traditional risk factors of CHD include hypertension, hyperlipemia, diabetes mellitus and smoke etc. By restraining of these risk factors, the pathologic course of atherosclerosis can be markedly put off or reversed and the occurrence of cardiovascular events can be reduced. However, about 50% early-onset CHD patients have no such traditional risk factors. Thus it seems very important to find out new CHD risk factors. There come more and more evidences showing that high level homocysteine (Hcy) in the blood is a new independent risk factor of CHD since 1969 when American scientists McCully et al found that most patients of high level Hcy in the urine are also suffering from cardiovascular diseases.Hcy is an amino acid containing sulfur and an intermediate product of the metabolism of methionine and cystaine. It is not involved in the synthesis of protein per se. Hcy has main three metabolic pathways: 1) Hcy is again mentholated to methionine under the effect of methionine...