CAMP Receptor Protein And Induced Differentiation In Gastric Cancer Cell Line

It has been shown that several different systems of signal trans-duction play an important role in the control of cell growth and differentiation, especially cAMP dependent signal transduction system. cAMP, an intracellular regulatory agent, has long been considered to have a role in the control of cell proliferation and differentiation in various cell types, and exerts its effect by binding to the receptor protein — the regulatory subunits of either type I or type I cAMP dependent protein kinases. Differential expression of these protein kinase isoforms has been observed during cell development, differentiation and neoplastic transformation. There are overexpression of R_I subunit in malignant tumor tissues and in cancer cell lines. It is suggested that the overexpression of R_I subunit may be related with overgrowth of the cancer cells. In the present study, we observed the effect of site-selective cAPM analog and antisense oligodeoxynu-cleotides of _Iα on the proliferation and differentiation in gastric cancer cell lines, and explored their antitumor mechanisms. The results were shown as follows:1. Inhibition of proliferation. 8-Br-cAMP, one of the site-selec-...