The Researches On Changes Of Migratory Ability And Corresponding Signaling Pathways In Oral Keratinocyte Stimulated By Candida Albicans In Vitro

Background: The importance of cell migration is evident from both the physiological processes that depend on the regulated movement of cells, including embryonic development, immune responses and tissue maintenance and repair, and from the disease states driven by aberrant cell motility, such as chronic inflammation, vascular disease and tumor metastasis. Not surprisingly, immense effort has been directed towards furthering our understanding of this complex process. Extracellular signal-regulated protein kinase cascade (ERK) is one of best characterized intracellular signaling pathways, which play a critical role in the control of cell survival, proliferation, and migration when activated by series of stimuli. Recently available information suggests that Candida albicans (C.albicans) have relationship with cell migration. However, the presumes between C.albicans and cell migration and corresponding signaling pathways are still largely unknown.Purposes: In this study, we set out to explore the possibility that C.albicans may elevate the migratory ability of oral keratinocyte through ERK pathway,...