The Inhibitory Effect Of Tanshinone On The Proliferation Of Vscular Smooth Muscle Cell And Restenosis After Intervention

Background: Percutaneous coronary intervention is currently one of the most commonly methods used to treat coronary artery disease, but restenosis is still the most important long-term limitation. Therefore, how to reduce the ratio of restenosis is challenges both in basic and clinic research. Nowadays it was widely accepted that proliferation and migration of vascular smooth muscle cells results in intimal hyperplasia after vascular injury are the key mechanism of restenosis. Tanshinone is one of the active components of Salvia miltiorrhiza Bge, and it has various pharmacological activities that may affect many vascular processes responsible for restenosis in theory. In addition, it's reported recently that tanshinone can inhibit proliferation of vascular smooth muscle cells. However, little is known about its antiproliferative mechanisms, and there is no directive evidence about its effect of preventing restenosis.Objective: The aim of this study was to investigate the effects of...