The Effect And Mechanism Of Hyperlipidemia To Electric Remodeling Of Rabbit Myocardium

Background: Lots of studies have manifested that hyperlipidemia was an independent factor associated with sudden cardiac death (SCD). Ventricular arrhythmia (VA) is the main reason of SCD in the patient who has hyperlipidemia. A study recently demonstrated that hyperlipidemia could increase the vulnerability to VA alone. But the mechanism remains unclear. Electrical remodeling due to rate is one of the most important mechanisms that contribute to the occurrence of VA. However, there is little to know whether hyperlipidemia has an effect on electrical remodeling. This study was designed to study the effect and the underlying mechanisms of hyperlipidemia on electrical remodeling, and to investigate the effects of simvastatin, enalaprol, or antioxidant to electrical remodeling in hyperlipidemia.Methods: The male New Zealand white rabbits were fed with chows rich in fat to induce hyperlipidemia. The rabbits were divided into 5 groups: control group, HC group, HC + simvastatin group, HC + enalaprol group, and HC + antioxidant group. Rabbits of control group were fed with standard chow, and rabbits of other groups were fed with 0.5% cholesterol and 10%...