Study On The Mechanism Of Mother-to-infant Transmisson Of Hepatitis B Virus

ObjectiveAbout 2 billion people were infected by hepatitis B virus in the world, among them, 0. 35 billion peple were HBV carriers. The average carrier rate of hepatitis B virus is 9. 7% in China. There are more then 30 million patients with chronic hepatitis B in china, and the total infection rate is up to 57. 8% . The infection of HBV was correlated with liver cirrhosis and hepatocellular carcinoma closely.Mother - to - infant transmission or called vertical transmission is one of the important transmission routes of HBV. About one - third infants infected with HBV were caused by vertical transmission. And about 95% infants infected by vertical transmission will develop into chronic HBV infection, which is a main reason for the high prevalence of hepatitis B in our country. Scholars are concerned about the study on the mechanism of mother - to - infant transmission of HBV and the protective measure to block up the vertical transmission. To block up the vertical transmission is the key point to control of the prevalence of HBV infection. Hepatitis B vaccine plays a good effect on the blocking of HBV vertical transmission. From 1988 hepatitis B vaccine was used in newborns as vaccinoprophylax-is, the infection rate of HBV in newborns has declined obviously. There are still about 10% newborns of HBV positive mothers were infected by HBV although vaccinoprophylaxis with hepatitis B vaccine. Intrauterine infection was the main cause for the failure of immune blocking of HBV...