| BackgroundAtherosclerosis is the pathological basis of cardiovascular and cerebrovascular diseases. It is the main cause of death in developed countries, as well as in developing countries, of which the morbitidy and mortality are getting higher and higher. So studies on the mechanism and the treatment of atherosclerosis have been the focus of intense research. There are three throries involved in the research on atherosclerosis, which are lipid infiltration theory, thrombogenic theory and reponse-to-injury hypothesis. With the development of the mechanism of atherosclerosis, Professor Ross R suggested "atherosclerosis: an inflammatory disease" based on reponse-to-injury hypothesis in 1999. Some chemical factors, cytokines and immunologic facrors are related to contact and interact all kinds of cells through autocrinism and paracrine secretion in atherosclerotic lesions, as a result of promoting the development of atherosclerosis. Numerous studies indicate that atherosclerosis is a multifactorial, complex pathological process. The main step is the deposition of low density lipoprotein-cholesterol, then oxidative modification, inflammation cell congregating, invading and activating, therefore atherosclerosis developed. The inflammatory response runs through the total process of atherosclerosis, which is tightly concered with the formation and stability of plaque. It is more important to stabilize plaque than to control thrombus and revascularization. Luhuang Granule is created by Professor Tang Shuhua, which is based on his clinical practice with satisfactory results. Luhuang Granule, consisting of Rhizoma Polygontal, Radix Plygoni Multiflori, Rhizoma Curcumae Longae, Flos Carthami, Rhizma Polgoni Cuspidati and Uniflower... |
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