The Influence Of Different Carbon Dioxide Models On The Proliferation And Invasion Of Human Ovrian SKOV₃ Cells In Vitro And In Vivo

In the last decade of the 20th century, laparoscopic areas have gained remarkable achievements. The advantages of minimally invasive surgery—including less pain, quicker recovery, and shorter hospitalization time—have been realized in patients with intra-abdominal malignancies. However, more and more concerns about the safety of laparoscopy treatment have been aroused. A few clinical trials have reported that port site tumor metastases (PSM) and higher peritoneal tumor metastasis (PTM), rapidly growth rate of residual carcinoma in laparoscopic procedures than opening procedures. Compared with traditional operative procedures, the main pathologicphysiolic difference between the two methods is cause by pnemumoperitoneum with carbon dioxide (C02). On the other hand, most of the complications are related with improper manipulation. Furthermore, no consistent conclusion of the in vitro and in vivo experiments about C02 and the proliferation, adhesion and invasion of carcinoma has been drawn.Therefore, this research is aimed to systematically observe the influences of different C02 pressure models to imitating realistic laparoscopic manipulation situation on the proliferate, adhesive and...