Proteomic Analysis Of Human Colorectal Cancer Cell Line SW480 In Response To Octreotide

Bakeground: Proteomics has already become the focus in the field of cancer research. It is acknowleged that proteomics is a new technical platform, which help explore the pathogenesis and optimal treatment of cancer. Today, cancer has become the first enemy of human being and its incidence and mortality has been increasing in the past decades. The treatment modalities of cancer include surgery, chemotherapy and radiotherapy. Recently, biotherapy has played an increasingly important role in its treatment, for example, somatostatin analogues are used clinically as first-line drugs for treatment of neuroendocrinal gastroenteropancreatic tumors. Meanwhile, it has been reported that somatostatin analogues also are effective drugs in the treatment of non-neuroendocrinal digestive malignancy. Clincally, octreotide is one of the commouest somatostatin analogues. Its mechanism of anticancer has been explored by the methods of immunocytochemistry, immunocyto-blotting and flow cyctometry. However, up to now, it is rarely reported in the literature that proteomics be used as a method for investigating octreotide anticancer mechanisim. High-throughput proteomic profiling and bioinformatics tools allow for examining complete changes in protein expression of colorectal cancer in response to octreotide. Identification of differentially expressed proteins may lead...