Combined Gene Therapy On Hepatoma-Bearing Mouse Model Through Inhibiting The Growth Of Tumor And Regulating The Immune Response

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with increasing incidence.It resists to conventional chemotherapy and radiotherapy. Now gene therapy is one of the most potential therapeutic methods of tumor bio-therapeutic methods. It may offer certain advantages in the treatment of HCC. But gene therapy is also restricted by many factors such as low efficiency of a single gene against tumor, toxicity o f transgenic vector, and tissue-specific expression of the target gene. It should be strongly envisaged that the combination of interest transgenes will greatly improve the treatment of HCC and decrease toxic side effect. In this research the gene therapy methods inhibiting the growth of tumor and activating the immune system were combined to treat HCC. During the study the efficient way and the possibility of combined way in HCC gene therapy were explored.The growth and progression of solid tumors is dependent on new blood vessels. Endostatin can specifically inhibit endothelial cell proliferation and induce endothelial cell apoptosis. Therefore it can inhibit the formation of new blood vessels, cut...