Study On The Mechanisms Of Cardiomyocyte Injury Induced By C-reactive Protein

BackgroundCoronary atherosclerosis disease (CAD) is the major cause of death in the developed world and increasing rapidly in developing countries. The pathogenesis of CAD is very complex. The injury of vascular endothelial cell, activity of platelet and factor, imbalance of procoagulation and anticoagulation, hyperlipoidemia and the change of haemodynamics could all contribute to promote the the development of atheromatous plaque and thrombopoiesis. But the initial cause and mechanism of CAD remained unclear. There are many hypothesis about the mechanism of CAD, among which, the inflammation hypothesis has been paid more and more attention. Evidences show that inflammation play a key role in the invasion, development and prognosis of CAD. So the study of the correlation betweens inflammation factors and CAD become a hot spot. It has important clinical significance to reveal the relation between the inflammation factors and CAD. Many clinic studies show that C-reactive protein (CRP) has been closely related with the invasion, development and risk stratification of CAD. It has been considered as the most powerful inflammation marker to predict the risk of potential CAD. But the inner relation between CRP and CAD remained unclear CRP is just a marker following the invasion, development of CAD (bystanders) or directly takes part in the pathogenesis (culprits)? Recent studies show that CRP can be found in the early atherosclerotic plaque, which suggests CRP may be related with the formation of early atherosclerotic plaque. Besides, CRP can attenuate endothelial progenitor cell (EPCs) survival, differentiation, and function. And CRP can induce apoptosis of human coronary vascular smooth muscle cells (VSMs) also. The highest...