The mucose of upper respiratory tract in the health host was colonizated numerous indigenous microbial flora, which the domination flora controls the integrity and stability of microcommunity structure and to be sure executing the physiological functions. The structure of indigenous microbial flora would be changed when the exogenous organisms invaded or the endogenous organisms translocation or dysbacteriosis. A balance is maintained among the strains of normal bacterial flora based on principles of antagonism and coexistence. The maintenance of this balance is one of the important prophylactic mechanisms, and a change in balance can therefore be presumed as one of the factors causing infectious diseases. Also, the identification of the bacterial species and determination of the microbial community structure were very difficulty due to existing uncultured microbial in the microbrance. Although a lot of projects on the indigenous microbial flora in the gastrointestinal tract has got a great successful, but about the normal bacterial flora was known a little in upper respiratory tract. Respiratory infections remain common and may be more difficult to treat because new microbes have been identified, commensal flora can become pathogens, and antibiotic resistance is developing, especially Streptococcus penumoniae, Streptococcus pyogenes and Haemophilus influensae. There were no direct method to assess the diversity of the genus and species has been developed so far. How about that the relation between the dynamic balance of microbial population and infectious diseases in upper respiratory tract? How do we apply the bacterial genetic unit of broad evolutionary interest as a tool using to identification and determination of bacterial species without...
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