| Diabetes mellitus has been widely recognized as a major health problem affecting many people's life around the world. Type 2 diabetes is the most common form of diabetes. Insulin resistance (IR), characterized by reduced responsiveness the normal circulating insulin in target tissues, is now considered as a fundamental aspect of etiology of type 2 diabetes and also link to a wide range of other pathologic defects such as impaired glucose tolerance (IGT), obesity, hypertension, hyperlipidemia and atherosclerosis. Exploring the molecular mechanism of IR and searching for potent insulin sensitizer has appeared to be an essential and important problem.Qian Jin Huang Lian pill (FF-V) is one of anti-diabetic Chinese Traditional Medicine (TCM) recipes being under development. It is a class of components that appear to enhance insulin action and show effectiveness in improving peripheral glucose utilization, reducing hepatic glucose production and ameliorating IR. Anti-diabetic effects of FF-V in cell and insulin resistance animal model are described in the dissertation. Several methods related to the research of insulinomimetic compounds are also being discussed.Part I Techniques for insulinomimetic compounds research on cell levelIn diabetes, there is a failure to increase glucose uptake into peripheral tissues in response to insulin, leading to chronically elevated levels of glucose in the circulation. A focus of current anti-diabetic medicine research is the development and research of compounds with potential insulinomimetic effects to stimulate rate of cell glucose uptake and utilization. A series of experiments were conducted to acquire optimized...
|
PDF Full Text Request