Association Of Candidate Gene With Hypertension, Target-organ Complications

Hypertension and its target-organ complications are very important public health problems in the world. Geneitc causes of hypertension, the genetic susceptibility to target-organ complications and the pharmacogenetics of antihypertensive therapy are very important aspects in the improvement of evaluation, prevention and treament of hypertension. ObjectionsThe aim of this study was to investigate the association of candidate gene of hypertension, target-organ complications and the treament of hydrochlorothiazide or felodipine. We observed the polymorphism of five genes including those of aldosterone synthase(CYP11B2), angiotensin II type 2-receptor (AT2-R), endothelial nitric oxide synthase, G protein beta3 subunit and a polymorphic HindIII restriction site in the nonrecombining region of the Y chromosome. The association of various combinations of the five candidate genes of hypertension and target-organ complications were also investigated. Materials and MethodsThis study was designed in a case-control manner. 654 patients with essential hypertension were enrolled into this study as the hypertensive group. The criteria of hypertension was based on the 1999 WHO/ISH guidelines (SBP≥140mmHg and/or DBP≥90mmHg). 386 normotensive subjects were enrolled into this study as the control group. Basal phenotyping included clinical history based on WHO/ISH guidelines, physical examination, laboratory tests, and completion of standardized questionnaires. Height and weight measurements were taken in the standard conditions, and body mass index(BMI) was calculated using the formula of BMI=W/H~2(Kg/m~2). Two-dimensional M-mode echocardiograms were performed in...