Overexpression Of Ribosomal Protein L15 Is Associated With Cell Proliferation In Gastric Cancer

BackgroundGastric cancer is the second most common cause of cancer death worldwide. Environmental and genetic factors are both important in gastric carcinogenesis. In recent years, knowledge about the molecular features of gastric carcinoma has increased rapidly. Loss of heterozygosity (LOH) on loci of chromosomes 1,5, 7,12, 13 and 17 were frequently identified in advanced gastric carcinomas. Genetic alterations such as activation of oncogenes and inactivation of tumor suppressor genes could often be found in gastric cancer. It was believed that mutation or amplification of oncogenes c-ras, c-erbB-2, K-sam, c-met, and c-myc and inactivation of tumor suppressor genes p53, adenomatosis polyposis coli (APC), deleted in colorectal carcinomas (DCC), and retinoblastoma (RBI) are related to the development of gastric cancer. These genes are the potential prognostic markers to predict progression and metastasis of gastric cancer.Recent studies have shown that comprehensive analysis of gene expression patterns can identify new molecules discriminating gastric cancer from normal gastric mucosa. This technique was also be used to distinguish tumor subgroups and identify genes whose expression may be correlated with disease classification, early detection,...