Mechanism Investigation Of The Transcriptional Regulation Of Myc On Human NDRG1 And NDRG2

The myelocytomatosis viral oncogene (Myc) was first identified as a cellular homolog of the viral oncogene homolog-myc (v-myc) from the retrovirus MC29 in 1978 by Bishop. Several research groups subsequently determined that the cellular-myc (c-Myc) proto-oncogene was activated in various animal and human tumors. Compared to undetectable pattern in most normal tissues, Myc is highly expressed in tumors. Myc regulates the proliferation and differentiation of the cells. The high expression level of Myc results in abnormal proliferation and the uncontrol of the cell cycle. Furthermore, the lethal embory of the N-myc or c-Myc knockout mouse show the...