Molecular Mechanisms Of Cell Adhesion Mediated Drug Resistance (CAM-DR) In Gastric Cancer Cells Induced By MGr1-Ag/37LRP

The major cause of chemotherapeutic failure for gastric cancer is multidrug resistance (MDR). It is highlighted that a novel mechanism of MDR, named cell adhesion mediated drug resistence (CAM-DR),induced by adhering to the extracellular matrix (ECM) around cancer cells. MGr1-Ag, identified in our institute, is a novel MDR-related molecule found in vincristine-resistant gastric cancer cell line SGC7901/VCR. It was proved that MGr1-Ag was identical to the human 37KDa laminin receptor precursor (37LRP). Previous studies showed that MGr1-Ag/37LRP was associated with MDR phenotype of gastric cancer cells. Investigating the functions of MGr1-Ag/37LRP, acting as a cell adhesion molecule (CAM), and its role in MDR will help to understand the development and modulation of gastric cancer MDR phenotype.Objective The purposes of present works are to study the chemotherapeutic drug sensitivity, exploit the mechanism of drug resistance in gastric cancer cells adhering to the ECM substrate, characterize the role and illuminate the molecular mechanisms ofMGr1-Ag/37LRP interacting with its ligand laminin in gastric cancer...