Construction Of Recombinant BCG Live Vaccine Expressing HCV Multiepitopes Antigen And Anylisis Of The Specific Immune Responses In Mice

Hepatitis C virus (HCV) is the main etiologic agent responsible for chronic hepatitis and liver cirrhosis in humans. About 55~85% of acute HCV infected persons can proceed into chronic infection, and 20% developed into liver cirrhosis, hepatocellular carcinoma and liver failure. Over 170 million people worldwide are estimated to be infected with HCV, the infected number of our country accounts for 50 million and is increasing. HCV infection and its related diseases have been viewed as a growing threat to human health worldwide and the severe problem of social public health. Currently there were no specific prophylactic and therapeutic vaccines except for part therapeutic effect with recombinant INF-α. It is urgent for developing prophylactic and therapeutic vaccine. Now many researches focus on DNA vaccine, subunit vaccine and viral vector vaccine, the deficiect in common is the elicitation of ineffective cellular immune responses. Exist of the HVR in HCV envelop glycoprotein E2 inhibits of the development of prophylactic vaccine. So recent years studies focus on construction of prophylactic and...