Evaluation The Genetic Toxicity Of Tributyltin Methoxide With Multiendpoint And Study On Its Molecular Mechanisms Of Apoptosis

Since 1960s, organotin chemicals have been started to be widely employed as an antifouling agent on water vessels, fishing net, ocean building, the artesian well platform, etc. Tributyltin is one of a kind that has most application and strongest function. However, due to its high degree of toxicity towards marine invertebrates, such as fungi, pests and mollusk, this toxicity also makes them ecological risk to nontarget organisms such as fish, mollusk, alga, which were found from lots of countries by 1980s. Tributyltin, which is also a kind of endocrine disrupting agent, has brought serious pollution problem to the ocean for that it could cause animal death, growth abnormality, imposex. The marine creature could enrich the organotin and so it may be toxic to the creature in low concentration by accumulation . Tributyltin might not only harm the marine creature, but also harm the human through food chain and food enrich effect. The toxicity of tributyltin is pay attention to by all countries and tributyltin chemicals are considered to be one of the most toxic anthropogenic substances to enter the marine environment. Lots of countries have restricted the use of tributyltin in aquaculture and on boats. Tributyltin is already defined as one of PTS (Persistent Toxic Substances) by United Nations Environmental Protection Administration and the world marine organization has issued the document that tributyltin would be stopped to use from 2008. Though tributyltin could be reduced the amount of entering the marine environment, however, tributyltin could exist in benthic sediment with high concentration in many areas for a long time particularly in the coast line region.Data on the genotoxicity as well as the mechanisms of tributyltin are, however, scarce. Many studies were concerned about its immunity toxicity and the endocrine disrupting function, while a few of them about its genetic toxicity to the marine creature. A study on its genetic toxicity carried on in mytilus edulis and platynereis dumerilli with the sister chromatid exchange assay, comet assay, micronucleus assay, chromosome aberration assay, and then the...