Effect Of Hypoxyradiotherapy On Normal And Tumor Tissues

It has been known that radiotherapy playa an important role in cancer treatment In order to controlor cure tumors, difinite doses which the radiother-ther apists are able to deliver are limited by the tolerance of surrounding normal radiosensitioe organs or . tissues.Hypoxic-radiotherapy, by having the subject breathing hypoxic gas prior to or during irradiation, can effect a protection on the normal tissue but not the tumor. This is due to a time and degree of differential in oxygen tension between the normal and neoplas-tic tissues.In the present experiment, we found that mice breathing a mixed gas (10. 5% Oxygen, 89.5% Nitrogen) 5 minutes prior in irradiation, the normal tissue can...