Studies On Platelet Function And Release Of Prostaglandins In Coronary Circulation In Patients With Ischemia Heart Disease

The interaction between platelet and vessel wall may play an i(?)portant role in the development of ischemia heart disease (IHD). In our research,we measured changes in platelet function and release of prostaglandins in coronary circulation to further study their propable role in different patterns of IHD.1.Changes in platelet function and prostaglandins levels in coronary circulation in patients with different clinical types ofIHDSimultaneous coronary sinus (CS) and ascending-aorta (AO) blood samples were obtained from 47 patients for measurement of plasma and serum thromboxane B₂ [TXB₂, a stable metabolite of thromboxane A₂ (IXA₂)] and of 6-keto-prostaglandin F₁a [ 6-keto-PGF₁a , a stable netabolite of prostacyclin I₂ (PGI₂)]. Samples from some of these patients were also tested for platelet aggregation and plasma. cAMP. The results showed (1) patients with unstable angina pectoris (UA) and acute myocardiol infarction (AMI) had higher plasma TXB₂ CS/AO ratios (1.66±0.20 and 2.32 ±0.47, respectively) than patients with stable angina (SA) and control subjects (1.04±0.17 and 1.00±0.06, respectively) (p<0.05); (2) serum TXB₂ CS/AO ratios in patients with SA, UA or AMI were significantly lower when compared with control subjects; (3)plasma cAMP CS/AO ratios were lower in patients with UA than those in patients with SA or control subjects; (4)platelet aggregation in CS blood significantly decreased than that in A0 blood in patients with UA,but there was no difference in platelet function between A0 and CS in control subjects; (5) no significant differences...