Functional MR Imaging In Evaluating Osteoporosis And Vertebral Fracture

Part one: Pilot study of vertebral bone marrow by MRSpectroscopy in rabbits Objective: The aim of the study was to evaluate the relationship between vertebral magnetic resonance spectroscopy (MRS) and histomorphology in rabbits. Materials and methods: A total of fifteen healthy Zelanian rabbits (mean age 8.6 ± 3.2 months, range 4~13months) underwent single voxel (SV) ~1H MRS examination at the lumbar spine (L7) with point resolved spectroscopy (PRESS) sequence. Lipid water ratio (LWR) was measured by SAGE 7.0 software. The vertebral body was dissected after MRS examination. Then the histomorphological slices were stained with H.E method. The Image-pro plus 5.0 software was used to analyze the histomorphological slices and to calculate the ratio of yellow bone marrow area to red bone marrow area in vertebral body. Results: Mean value of LWR of the vertebral body was 0.881±0.59 (range 0.263~2.594). The mean yellow/red bone marrow ratio from histomorphological slices was 1.166±0.88 (range 0.114~ 3.457). A positive correlation was found between LWR and area ratio (r=0.817,P<0.01). The linear regression equation from the correlation was obtained (LWR=0.24+0.55 × area ratio). Conclusion: LWR could partially reflect the yellow/red bone marrow ratio in vertebral body. The changes of vertebral bone marrow could provide a histomorphological basis for the vertebral MRS.Part two: Potential value of vertebral proton MR Spectroscopyin determining osteoporosis and vertebral fractureObjective: To investigate the correlation between vertebral proton...