The Clinical Study Of Cytokines And Growth Of Vascular Endothelial Cells In Hepatocarcinoma

Objective: To determine the serum levels of cytokine IL-1α , IL-1β , IL-2 , IL-4 , IL-6, IL-8, IL-10, VEGF, IFN γ, EGF , MCP-1 and TNF α in patients with hepatocarcinoma and investigate the effect in growth of Vascular endothelial cells in hepatocarcinoma(HCC). Methods: 30 patients with hepatocarcinoma were taken as HCC group;30 patients with hepatocirrhosis were taken as hepatocirrhosis group;30 normal health examinees were taken as the normal control group. The fasting peripheral blood of all subjects was collected in the morning and centrifuged. Cytokines had been measured by biochips methods in evidence 180 automatic biochips analyze. Results: The serum levels of IL-1 β IL-6 IL-8. VEGF and EGF of the patient with HCC and cirrhosis were significantly higher than those in normal control group. The serum levels of IL-10 IFN γ and TNF α of the patient with HCC and cirrhosis were significantly lower than those in normal control group. The serum levels of IL-1 β IL-6 IL-8 VEGF and EGF of the patient with HCC were significantly higher than those in the patient with cirrhosis. The serum levels of IL-10 and TNF α of the patient with HCC were significantly lower than those in the patient with cirrhosis. The serum levels of IFN γ of the patient with HCC had not significant difference of those in the patient with hepatocirrhosis Conclusions These results suggest that the serum levels of angiogenic factors in HCC were increased. The serum levels of the inhibitors of vascular endothelial cells in HCC were decreased.