Effect Of Tongfutang On Gut Barrier Of Abdominal Compartment Syndrome

1 Background and ObjectiveIntestinal tract is not only an organ of absorptive and digestive, but also an important organ in the non-specificity anti-infection system. Integrity of gut barrier is the foundation of the multiple function of intestinal tract to keep normal. When gut barrier is injured in the trauma and infection, plenty of bacteria and endotoxin intrude into general circulation trough portal vein and lymphatic system, and induced gut origin sepsis and endotoxemia, which will stimulate cascade reaction of cytokines and mediators of inflammation,making multiple organ suffered. Thus intestinal tract is regarded as motive power of multiple organ dysfunction syndrome. Intra-abdominal pressure increases in abdominal compartment syndrome patients. Blood flow of mesenteric artery, hepatic artery, mucous membrane of small intestine, microcirculation of liver and portal vein decreases. Intestinal mucous membrane and submucous tissue anaerobic metabolism, acidosis and ischemical reperfusion injury are occurred. Gut barrier is injured and causing bacteria and endotoxin translocation. Therefore studying the variation regularity of intra-abdominal pressure, the effect of abdominal compartment syndrome on the gut barrier, and investigating the protective method of gut barrier are important.Tongfutang is an empirical formula of professor Li Naiqing and a preparation of Dongzimen Hospital of Beijing University of Chinese Medicine, which has been used for more than 30 years. In the treatment of acute sever pancreatitis, retardation of enterokinesia after subtotal gastrectomy and paralytic ileus, it can ameliorate abdominal distention, stomachache, promote bowel sound to recover,promote defecation and breaking wind. The investment based on professor Li's long time clinical study of the preparation, adopting modern investment method of integrated Chinese and Western Medicine, using quantitative analysis technique, study the variation regularity of intra-abdominal pressure, the effect of intra-abdominal pressure on the blood pressure and intestinal mucosa permeability. Compared with glutamine, study the effect of Tongfutang on intra-abdominal pressure, the intervention in gut barrier dysfunction of abdominal compartment syndrome, and the influence on mesentery microcirculation. The effect of Tongfutang on intra-abdominal pressure of patients after alimentary tract malignant tumor surgery is observed clinically.2 methodsThe study investigate the pathologic physiology basis, treatment and clinical prevention...