The Study For The Mechanism Of Treating The Pharyngeal And Laryngeal Cavernous Hemangioma With Pingyangmycin

As the basis of our research, the experience of the treatment for pharyngeal and laryngeal cavernous hemangioma with PY was retrospectively analysed. The in vitro study showed PY has necessary inhibiting effect on ECV304 cells. It could regulate the cell cycle of the ECV304 and then induce AP. During the AP process Caspase-3 activity enhanced, P53 protein expression increased, while Bcl-2 protein experession unchanged, and the telomerase activity was inhibited. PY could cause mice spleen sinusoid shrinking, the apoptosis of spleen sinusoid endothelial cells, accompanying with a little necrosis and fiber tissue proliferating. At the same time Caspase-3 activity and P53 protein increased, while Bcl-2 level unchanged. It is showed that the main mechanism of the treatment for laryngeal and pharyngeal CA is through inducing vessel endothelial cell apoptosis. The apoptosis is dependent on the increment of Caspase-3 and P53 protein expression, and the inhibiting of the telomerase activity.