The Investigation On The Mechanism Of Cardiovascular Effects Of Endothelin-1_1-31

Abstract: ET-1_1-31, a novel member of the endothelin family comprising 31 amino acids and derived from the selective hydrolysis of big ET-1 by chymase. Although the peripheral effects of ET--1_1-31 have been well determined, the cardiovascular role of ET--1_1-31 is not fully understood. Our study suggested that administration of ET--1_1-31 through coronary artery increased blood pressure of rats. Central administration of ET--1_1-31 produced biphasic cardiovascular effects. The central effects of ET--1_1-31 which were mediated through ETA receptors and did nothing with ETB receptors, result from ET--1_1-31 converting to ET--1_1-21 ET--1_1-31 increase [Ca²+]I, but 10^-8 mol/L terminated [Ca²+]I, which were partly attenuated by phosphoramidon.