| Purpose: To evaluate the validation of high-resolution magnetic resonance imaging and new post processing software in quantitive analysis of vessel model, healthy volunteers and the artery status of patients with coronary artery disease (CHD patients). To dynamically monitor and assess the therapeutic effect of Statin in patients suffering from coronary atery disease.Methods: l)validation study-to assess the accuracy by quantitive measurement of the wall area and maximum wall thickness of vessel model with high resolution magnetic resonance imaging and new post processing software. To measure the wall thickness and wall area of aortic and carotid arteries in healthy volunteers, and to assess the repeatability of this method by intra-observer, inter-observer and inter-test study. 2) Controlling study in CHD patients and healthy volunteers- To get MR image in aorta, carotid arteries and brachial artery in healthy volunteers and CHD patients and measure the wall area, maximum wall thickness, distensibility and hemodynamic parameters. To evaluate the endothelial function of brachial artery and assess the abnormality of function and anatomy in both central artery and peripheral artery of CHD patients. 3). Theraputic effect evaluation-to scan the aorta, carotid arteries in CHD patients with Simvastatin therapy before treatment, after 3 months of treatment and after 1-year treatment, respectively. To compare the wall area and maximum wall thickness of vessels and assess the therapeutic effection of Simvastatin to atherosclerosis.Results: 1) In validation study-there's good correlation between the diameters ofvessel model and the data of magnetic resonance imaging. The coefficient of inner vessel wall, outer vessel wall and wall area was r=1.0, 1.0, 1.0, P<0.001, P<0.0001, P<0.0001, respectively. There were high correlation between all of the 6 vessel models and the MR data(r=0.99, P<0.0001) .The inner area, outer area measurement for twice in healthy volunteers by observer A showed high correlation(R=1.0; R=0.99; R=0.99, respectively), so was the maximum wall thickness(R=0.93).In inter-observer study, the inner, outer wall area and wall area of vessel in two times showed high correlation (R=0.95; R=0.95;R=0.92), and the variability of vessel wall thickness was much lower, comparing with that of the Intra-obersever study (R=0.83) .In repeatability study, the vessel wall measurement of 10 volunteers showed good correlation(R=0.96), while the coefficient of maximum vessel wall thickness was lower (R=0.81) .2)In controlling study-there was no difference of the outer area, inner area of descending aorta and bilateral carotid arteries between CHD patients and healthy volunteers(P>0.05, respectively), but the wall area and maximum wall thickness of descending aorta and bilateral carotid arteries in CHD patients were much higher than in healthy volunteers(in aorta and carotid wall area comparison, P<0.05, P<0.05, P<0.05, respectively, in aorta and carotid maximum wall thickness comparison, P<0.001, P<0.001, P<0.001, respectively). The distensibility was lower in CHD patients(P<0.05, P<0.01, P<0.05 in ascending aorta, descending aorta and abdominal aorta, respectively), so was the distensibility of common carotid artery(p=0.03).The distensibility of brachial artery in CHD patients was similar to that of controls (P=0.58), and there was no magnificent difference of aortic flow(forward, reverse and net flow, P=0.72, P=0.80, P=0.51, respectively), flow output(P=0.70) and peak blood velocity(ascending, descending and abdominal aorta, P=0.47, P=0.59, P=0.88, respectively) between the two groups. The PWV(pulse wave velocity) in proximal aorta(including ascending aorta and aortic arch) was lower in CHD patientsthan in control (P<0.05), while there was no difference of the PWV of distal aorta in two groups (P=0.30) .The endothelial dependent FMD(flow medidated dilation) effect in brachial artery was lower in CHD patients than in controls, both in absolute area change and in relative value(p<0.05; p<0.01, respectively), but there was no...
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