Study On The Mechanism Of Prevention And Treatment Of Coronary Heart Disease With Yiqihuoxue Prescription

YiQiHuoXue prescription is based on a quantity of patients with CHD by my tutor. In order to investigate the therapeutics, recipe and combination principle of YiQiHuoXue prescription, and to demonstrate the mechanism of its prevention and treatment of coronary heart disease(CHD). In this treatise, through animal experiments in which animal models are made, and with advanced techniques such as optic microscope, immunochemistry and biochemistry, the composite mechanism closely related to the happening, development, prognoses and trend later of CHD are studied on the cellular and molecular level, so that the mechanisms of how YiQiHuoXue prescription can play an influential role in prevention and treatment of CHD can be deeply probed into.The results show that, the YiQiHuoXue prescription can not only reduce LDL-c , TC, TG in plasma but also raise HDL-c content significantly , it also can inhibit TC disposition in vascular cliff, and TC/HDL figure is lower .The YiQiHuoXue prescription can obviously inhibit releasing platelet activating factor TXA2 and TXB2/6-keto-PGF1 figure is low , possess a quite strong agonistic effect of restrain platelet aggregation and ant thrombosis function. The YiQiHuoXue prescription can depress or disrupt the level of IL-6, IL-8, expression of E-selectin , IL-1 by activate of vascular endothelial cell, reduce expression ratio of adherence molecular CD11b. The YiQiHuoXue prescription play a role in prevention and treatment of injury of vascular endothelial cells and vascular smooth muscle cells proliferation by ox-LDL. So it shows YiQiHuoXue prescription intervene inflammatory reaction , since inflammatory reaction take an active part in the procedure of CHD.Above results show that YiQiHuoXue prescription can protect injury of vascular endothelial cell, restrain platelet aggregation, intervene inflammatory reaction , inhibit vascular smooth muscle cells proliferation .In conclusion YiQiHuoXue prescription will be a compound agent of TCM with a brilliant prospect of prevention and treatment of CHD.