The Research About Protective Efficiency And Safety Of DNA Vaccine Against Lymphocystis Disease Virus (LCDV)

The requirement for additional or alternate sources of fish and shellfish has prompted the rapid growth of the aquaculture industry worldwide, which has resulted in the outbreak of aquaculture animal diseases, especially the prevalence of viral infectious diseases. Disease control is a major concern for aquaculture.Lymphocystis disease (LCD) is an infectious disease of several seawater fish species. LCD and its causative agent, fish lymphocystis disease virus (LCDV), exist worldwide, and the rate of incidence appears to be increasing. LCDV belongs to the Iridoviridae group of viruses. It can infect approximately 125 different teleosts, both naturally and experimentally. The skin of the infected specimens is often covered with raspberry-like lesions. Sometimes, small, white and pearl-like nodules are formed over the whole body, spreading from the gills to the fins. Because diseased fish cannot be commercialized, an important economic loss was resulted in aquaculture systems. LCDV have been occurred in Shan dong province since 1997 and resulted in a large economic loss. As an alternative to chemical and antibiotic treatment, a DNA vaccine is the best method for the prevention of infectious diseases in farmed fish, especially viral infectious diseases. It became a new research hotstop that adopting vaccine to prevent and cure of disease on aquaculture animals.DNA vaccines offer a method of immunization that overcomes several disadvantages (such as the risk of infection and high cost) of traditional live attenuated, killed or subunit protein-based counterparts. Vaccines can induce strong and long-lasting humoral and cell-dependent immune responses and possess several practical and economical advantages that making them attractive for the aquaculture industry. Antigen synthesis induced by DNA vaccination imitates natural infection by intracellular pathogens and leads to subsequent cell-mediated responses and ultimately the generation of memorial lymphocyte responses.Research regarding DNA vaccines for fish commenced relatively recently and...