Research On The Detecting System & Atlas Of Neuron-threshold And Its Application In Clinic

Due to the specificity of neurology, basic neurological researches have been advancing at a relatively slack pace. During the 1970's~1980's, the difficult problems in locating epilepsy without organic changes and its surgical treatment were properly solved by engineering approaches. However, it is still impossible to diagnose and treat the behavioral function impairments caused by external-factor-induced changes in neuroelectrical characteristics. The present paper aims at developing new methods for basic neurological researches and novel approaches to the diagnosis and treatment of neurological diseases by investigating neuroelectrical characteristics(mainly neuron threshold values).Firstly, a description is made of the concept, characteristics and mechanism of the neuron threshold values, with emphasis on the neuron threshold detecting system and the significance of its clinical application. An introduction is given to the scope, cases and results of the application of the system and the atlas, particularly the positive effects achieved in clinical treatment of neurological diseases..Secondly, a demonstration is offered on the neuroelectrical signal transmission and its mechanism, together with the function of the ionic channel in the neuroelectrical signal transmission. A neuron electrical model was established. And a study was made on the generation of neuronbio-electricity , and the influence of the neuron membrane equivalent circuit and membrane circuit parameters on the electrical signal time slot and transmission efficiency and speed.With respect to the neuroelectrical characteristics of nonlinearity and weak signals, proposals are advanced on the design requirements of software and hardware of the system, the principles for general design and hardware selection, and the methods and steps for software design. A neuron threshold detecting system was developed; the animal experiment protocol for neuron threshold atlas was explored; the methods for experiments and result analyses were established; and both theoretically and practically significant conclusions were derived from statistical analysis of different waveforms, duty rates and intensities of the signals as well as by evaluation of the results by spectrum analysis method.Lastly, an account is given of the significance of the establishment of neuron threshold atlas in the basic researches on neurology and biomedical engineering. And suggestions are ventured for further studies.