Investigation On Some Key Technologies Preparing Spherical Pellets By Extrusion-Spheronization

Spherical particles prepared by extrusion-spheronization technology, have higher production efficiency, better roundness characteristics and higher mechanical properties; moveover environmental health of the production process, simple of the process and equipment, nearly half a century, it is widespread use in food, feed, cosmetics and other industries at home and abroad. Although Extrusion spheronization Granulation shows its great advantage was widely used, but there are still some key issues unresolved.This texts was aimed at construction of a ideal wetting and mixing stick-plastic,state of material which was suitable for extrusion spheronization, combined particle preparation comparative experiments with analysis of mechanism, through research on the viscosity reduction methods of dry extract of Chinese medicine Rhinitis and viscosity enhancement methods of inorganic alumina material, by depth analysis of the mechanism of moisture bonding of Chinese traditional medicine extract materials, the effect of operating parameters on product apparent quality and catalytic properties in inorganic alumina spherical catalyst preparation process, provide a theoretical basis to achieve applications in the broader field for extrusion spheronization technology. The main research work and innovations are as follows:(1) Basic theoretical research.This paper analyzes the wetting mechanism of water and microcrystalline cellulose, from hydrogen bonding, van der Waals force, the role of molecular diffusion bonding discussing the relationship between the different of the wetting force of molecule and the ideal viscosity mixture. Analysis the mechanism of kinetic transformation to the surface energy during breaking, derived the potential breaking formula which reflect the intrinsic relationship of breaking effect about chassis friction rotation speed and materials length. By establishing the model of motion and particle deformation, system analysis the general sports law of overall materials and the movement type of single particle during spheronization process, the main deformation force of the particles spheronization into the ball, and to quantitative analysis the deformation force of playing major role.(2) The research of improving the level of Chinese medicine extract pellets containing drug. Issues of water and the wetting process of Chinese traditional medicine extract, ethanol extract of the wetting process and traditional Chinese medicine, from the coordination chemical bonding, electrostatic and hydrogen bond angles of over-associating traditional Chinese medicine extract materials discussed bonding mechanism of moisture. By traditional Chinese medicine-β-cyclodextrin inclusion compound experiment, comparison device for measuring the viscosity, medicine extract pellets Biyankang experimental, comparative study of various accessories targeted amount of viscosity reduction method, in effectively reduce the viscosity of the same time, reached a modest goal of reducing the amount excipients. (3) The construction of inorganic alumina powder granulation suitable for extrusion-spheronization visco-plastic system.Through the particles preparation experiment, selecting the best bonder, help squeeze agent, excipient which necessary to inorganic alumina powder extrusion spheronization process. Through analysis and application of the adhesive bonding mechanism of the surface of powder particle between organic and inorganic, analysis and application of coupling agent modification mechanism, based on the preparation of spherical alumina-based catalyst, further research how to improve product roundness and intensity of measures and how to change the parameters and granulation process to obtain the better final product performance and apparent quality.(4) The granulation practice of the extremely viscosity performance of the material. In this paper, self-developed patent product pellet granulator machine was the main experimental equipment, Rhinitis extract powder was the representative of high-viscosity Chinese medicine materials, ultra-fine alumina powder was a typical representative of inorganic powders, the best formula and process operating parameters were confirmed through by a large number of experiments and the preparation process of the carrier performance was focused and discussed.