Establishment Of BGH Transgenic Mice And Studies On Its Characteristics Andinfluencing Factors

Transgenic animal is one of the abvanced techniques developed in recent years. It has made great contribution to biology not only through it's technique but also through it's application. So far, the great achievements made through it's application have shown it's great vista in many fields,such as molecular biology, molecular gene tics, tumour engineering and animal sciences.So, many scientists and researchers are spending their time and energy to devot themselves to this new field.In 1982, Dr.Palmiter of Department of Biochemistry, Medical school, WashingtonUniversity, fused the promoter of metallothionein-I gene to the structural gene of bovine growth hormone in vitro, then microinjected it into pronuclei of fertilized mouse eggs, and first of all was successful in establishing the significantly larger than their littermates—supermouse in the world. Following that,many suggestions and resrarches were made, much valuable information was obtained...