| Non-thermal effects of electromagnetic fields and its mechanism have become a forefront project in the field of bioelectromagentics . It is also a new key project in the environmental protection. There have been large numbers of epidemiological surveys and cellular and molecular studies,which have described adverse health effects, especially, an association between long-term exposure to low-level extremely low frequency (ELF) magnetic fields (MF) and an increase incidence of adult and childhood cancers. However, what is lacking at the basic science end of these issues are robust cellular effects which have been replicated in different laboratories and a basic understanding of the mechanism by which EMFs couple to biological system, influence and alter key biological processes, and ultimately generate a beneficial or deleterious outcome. A general disagreement on the non-thermal effects of MF still persist In recent years, considerable effort has been turned to electromagnetic field-induced alterations in gene expression. From 1988 to 1992, Goodman et al reported that ELF MF exposure (5.7, 57 and 570 μT ) increases c-myc in HL-60, Phillips et al reported that 0.1 mT MFs increase c-fos and c-myc expression in CCRF-CEM T-lymphoblastoid cells. These results from two independent laboratories support the plausibility of an EMF-cancer linkage in some degree, which lead to great response in the bioelectromagnetics field. Since many similar studies yielded negative results , whether MF can influence the oncogenes transcription especially in the HL-60 and Daudi cell models becomes a doubtful point At 1996 International BEMS Meeting, considerable reports on replication of Goodman et al and Phillips et al were quite controversial, a large part of the results reported were negative. Notably, Binninger et al exposed the yeast Saccharomyces cervisiaer to 20μT 60 Hz MF for 24 hrs and identified characteristically five EMF-responsive genes (three known , two unknown) by using...
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