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Keyword [dhfr]
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21. The Relationship Between The Methylation Of Hcy Metabolism-related Genes And Ischemic Stroke
22. Design,Synthesis,Biological Evaluation And Molecular Modeling Of Novel Classical And Non-Classical Folic Acid Antagonists
23. Multi-timescale dynamic effects of antifolate binding and mutations in dihydrofolate reductase
24. Characterization of folate cycle enzymes in Plasmodium falciparum: Ligand binding properties of dihydrofolate reductase, thymidylate synthase, and serine hydroxymethyltransferase
25. Computational studies of Escherichia coli DHFR: Drug design, dynamics, and method development
26. Structure-based drug design for dihydrofolate reductase
27. Mechanisms of methotrexate resistance and toxicity in transgenic cell lines and flies
28. Structure based drug discovery of potent and specific antimicrobial agents for anthrax
29. Structural and Mechanistic Studies of a Bifunctional Enzyme from Pathogenic Protozoa: Probing Interdomain Communication and Selective Inhibition of T. gondii Thymidylate Synthase-Dihydrofolate Reductase
30. Mechanistic and structure-function analysis of thymidylate synthase-dihydrofolate reductase from protozoal parasites: Implications for the development of non-active site inhibitors
31. Hormonal regulation of genes involved in purine and pyrimidine biosynthesis and metabolism in human breast cancer cells
32. Design and synthesis of antifolates as inhibitors of dihydrofolate reductases in opportunistic pathogens (Pneumocystis carinii, Toxoplasma gondii)
33. Growth and productivity of a recombinant Chinese hamster ovary cell line in batch culture
34. The effect of gene localization on RNA processing
35. Dihydrofolate reductase: Translational regulation and effects of mutations on binding and catalytic efficiency
36. Folate-based antimicrobial agents
37. Synthesis and Evaluation of Co-drugs Derived from Methotrexate and Ibuprofen for the Treatment of Psoriasis
38. Metformin Decreases Hepatoma Cell's Resistance To MTX Or 5-FU Via Inhibiting DHFR And TS
39. Ligand Fragments Screening For Three Proteases Based On Biophysical Methods
40. Research On The Mechanism Of Wuzi Yanzong Pill In The Prevention And Control Of Neural Tube Defects Based On PI3K/Akt Signaling Pathway
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