| Objective: This study aims to observe the clinical efficacy and safety of Guiqi Rongxue Tang in the treatment of neutropenia with heart and spleen deficiency syndrome.It aims to observe the improvement degree of neutropenia,traditional Chinese medicine syndrome score,safety indicators,and efficacy indicators of Guiqi Rongxue Tang from multiple aspects and angles,and objectively evaluate the objective efficacy and safety of Guiqi Rongxue Tang in the treatment of neutropenia,providing a basis for clinical screening of reliable treatment plans,To provide another clinical comprehensive intervention method for the diagnosis and treatment of neutropenia with heart and spleen deficiency syndrome in traditional Chinese medicine.Method: This study selected 62 patients with heart and spleen deficiency syndrome of neutropenia who met the inclusion criteria from the outpatient and inpatient departments of Hengyang Hospital Affiliated to Hunan University of Traditional Chinese Medicine.They were randomly divided into a treatment group and a control group in a 1:1 ratio.According to the order of patient enrollment,they were assigned to the treatment group and the control group with corresponding numbers.31 cases were observed in both the treatment group and the control group.The treatment group received basic treatment and Guiqi Rongxue Tang,with a course of3 months;The control group received basic treatment.Both groups undergo regular blood routine examinations,and observe,record,and compare changes in relevant therapeutic and safety indicators such as neutrophil count,white blood cell count,and traditional Chinese medicine syndrome scores before and after treatment for 3 months.After organizing the data,SPSS statistical software was used for statistical analysis and processing to preliminarily explore the efficacy and safety of Guiqi Rongxue Tang in treating neutropenia.Result: After strictly following the criteria for detachment,termination,and exclusion,this study ultimately included 62 clinical observation cases,including 31 cases in the treatment group and31 cases in the control group.After statistical analysis using SPSS software,the results are as follows:(1)Baseline comparative analysis of general data: Before treatment,there was no statistical difference(P>0.05)between the treatment group and the control group in terms of gender,age,traditional Chinese medicine syndrome scores,and other general data,indicating comparability and research value.(2)Analysis of the changes in the grade of centriole neutropenia,the number of neutrophils and the number of white blood cells: The grade of neutropenia in both groups decreased after treatment,P<0.05,with statistical significance.The comparison between the two groups before and after treatment(P<0.05)showed statistical significance.The comparison of the number of neutrophils and white blood cells after treatment showed statistical significance(P<0.05).(3)Analysis of the changes in the scores and total scores of various syndromes in traditional Chinese medicine:(1)Analysis of the scores of various syndromes in traditional Chinese medicine: Before treatment,the comparison of the scores of various syndromes in the two groups was P>0.05,and the differences were comparable.After treatment,P=0.157(P>0.05)showed a statistically significant difference in improving fatigue and fatigue,and the treatment group had lower scores than the control group,indicating that the treatment group was significantly better than the control group in improving fatigue and fatigue.The other syndromes were all p<0.05,but the treatment group showed more significant improvement in improving dizziness,dizziness,and pale complexion compared to the control group.After treatment,the comparison of data in each group was P<0.05,and the decrease in scores in the treatment group was significantly greater than that in the control group,indicating that the treatment group was superior to the control group in improving various traditional Chinese medicine syndromes.(2)Analysis of total points of traditional Chinese medicine symptoms: Comparison between pre treatment and post treatment groups: The points of traditional Chinese medicine symptoms in both groups decreased after treatment,P<0.05,and the difference was statistically significant;Comparison between groups: The decrease in traditional Chinese medicine syndrome scores in the treatment group was significantly greater than that in the control group,with P=0.000(P<0.05),and the difference was statistically significant.The treatment group was significantly better than the control group in reducing traditional Chinese medicine syndrome scores and improving patients’ clinical symptoms.(4)Comparison of total efficacy between the two groups: The effective rate after treatment in the treatment group was 90.33%,while the effective rate in the control group was 77.42%,P=0.021(P<0.05),with a statistically significant difference.(5)Analysis of Traditional Chinese Medicine Syndrome Efficacy: Compared before and after treatment,the total effective rate of the treatment group was 80.65%,while the total effective rate of the control group was 58.07%.Intergroup comparison analysis showed a significant statistical difference of P=0.003(P<0.05).The therapeutic effect of the treatment group was significantly better than that of the control group.(6)In terms of KPS score: Both groups had lower KPS scores after treatment than before,but the treatment group was significantly better than the control group in improving KPS score.(7)Safety analysis: Both groups of patients showed no significant abnormalities in safety indicators such as liver,kidney,and electrolytes before and after treatment.Explain that our safety is acceptable.Conclusion: The research results indicate that Guiqi Rongxue Tang has a definite therapeutic effect on neutropenia with heart and spleen deficiency syndrome.It can effectively increase the number of neutrophils and white blood cells,improve clinical symptoms,reduce traditional Chinese medicine syndrome scores,and has good safety.It has practical value in clinical practice and further clinical and experimental research significance. |
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