| Purpose:In this study,five-tone therapy of traditional Chinese medicine was carried out on the elderly with kidney essence deficiency type dementia,to explore the clinical effect of five-tone therapy on the psycho-behavioral symptoms,cognitive function and TCM syndrome of the elderly with kidney essence deficiency type dementia,in order to provide reference for the intervention measures of five-tone therapy in the future patients with dementia.Material and method:This study is a randomized controlled trial in an experimental study.From July,2022 to December,2022,66 elderly patients diagnosed with dementia and syndrome differentiation of kidney and essence deficiency were selected from provincial geriatric hospitals.The subjects meeting the inclusion and exclusion criteria were randomly divided into the experimental group(33 cases)and the control group(33cases)by random number table method.The control group received conventional treatment and nursing methods,and the experimental group added five-tone therapy on the basis of the control group.The Neuropsychiatric Inventory(NPI-Q)and The Minimental State Examination(MMSE)and TCM syndrome score table were used to evaluate the intervention effect of the psychobehavioral symptoms,cognitive function and TCM syndrome in the two groups of patients before and after 12 weeks of treatment.SPSS26.0 software was used for statistical analysis of the data.The measurement data were consistent with normality.Independent sample t test was used for comparison between groups,and paired sample t test was used for comparison within groups.Non-normality was compared by Mann-Whitney U test between groups and Wilcoxon signed rank test within groups.Measurement data were expressed as mean ± standard deviation;Counting data were compared between groups using Chi-square test and described in terms of number of cases(percentage).Results:1.Baseline comparison There was no statistically significant difference in the general data(including demographic and sociological data such as gender,age,education level,marital status and clinically relevant data such as disease duration and disease classification)between the two groups before the intervention(P>0.05),and the differences were comparable.There was no statistically significant difference in the total scores and the scores of each dimension of the Neuropsychiatric Questionnaire(NPI-Q),the Simple Mental State Inventory(MMSE)and TCM syndrome accumulation table between the two groups before the intervention(P>0.05),and the differences were comparable.2.Psychobehavioral symptoms Comparison within group: After intervention,the total score of NPI-Q,delusion score,agitation score,indifference score,irritability score and sleep score of experimental group were decreased compared with before intervention,and the difference was statistically significant(P<0.05).After intervention,the total score of NPI-Q,agitation score,indifference score and sleep score of control group were decreased compared with before intervention,and the difference was statistically significant(P<0.05).Comparison between groups: After intervention,the total score of NPI-Q,indifference score and sleep score of experimental group were lower than those of control group,and the difference was statistically significant(P<0.05).After intervention,the total effective rate of mental behavior symptoms in the experimental group was 83.3%,and that in the control group was 13.3%.There was statistical significance in the total effective rate of psychobehavioral symptoms between the two groups(P<0.05).3.Cognitive function Comparison within group: After intervention,the total score of MMSE,the score of orientation,the score of recall,the score of language and visuospatial ability of experimental group were slightly improved compared with before intervention,and the difference was statistically significant(P<0.05).After intervention,the total score of MMSE,the score of orientation,the score of memory,the score of attention and numeracy,the score of language and visuospatial ability of control group were decreased slightly compared with before intervention,and the difference was no statistical significance(P>0.05).Comparison between groups:After intervention,the total score of MMSE and the score of language and visuospatial ability of experimental group were slightly higher than those of control group,and the difference was statistically significant(P<0.05).After intervention,the total effective rate of cognitive function in the experimental group was 56.7%,and the total effective rate of cognitive function in the control group was 13.3%.The difference between the two groups was statistically significant(P<0.05).4.TCM syndromes Comparison within group: The total score of TCM syndrome accumulation table of experimental groups decreased after intervention compared with before intervention,and the difference was statistically significant(P<0.05);The total score of TCM syndrome accumulation table in control group decreased after intervention compared with before intervention,the difference was statistically significant(P<0.05).Comparison between groups: After intervention,the total score of TCM syndrome accumulation table in experimental group was lower than that in control group,and the difference was statistically significant(P<0.05).After intervention,the total effective rate of TCM syndromes in experimental group was96.7%,and that in control group was 73.3%.The difference between the two groups was statistically significant(P<0.05).Conclusion(s):Five-tone therapy can can improve psycho-behavioral symptoms,cognitive function and related TCM signs and symptoms in elderly people with dementia with kidney essence deficiency. |
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