Clinical Observation On The Treatment Of Phlegm-dampness Obstructing Lung Syndrome In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease With Modified Sanzi Yangqin Decoction Combined With Acupoint Applicatio

Objective:To observe the clinical efficacy and safety of Modified Sanzi Yangqin Decoction combined with acupoint application in the treatment of patients with phlegm-dampness blocking lung syndrome during acute exacerbation of chronic obstructive pulmonary disease.Methods:In this study,60 patients who met the inclusion criteria were randomly divided into the treatment group and the control group,with 30 patients in each group.The control group was treated with conventional Western medicine,and the experimental group was treated with modified Sanzi Yangqin Decoction and acupoint application on the basis of the control group.The changes of blood routine,C-reactive protein,TCM syndrome score,CAT score,oxygen partial pressure and carbon dioxide partial pressure in arterial blood gas analysis and safety indexes of the two groups were observed before and after treatment.Results:1.Before treatment,there were no significant differences in gender,age and course of disease between treatment group and control group（P>0.05）.There were no significant differences in TCM syndrome score and CAT score（P>0.05）.There were no significant differences in the inflammatory markers of white blood cell count and CRP（P>0.05）.There were no significant differences in arterial blood gas indexes（Pa CO₂and Pa O₂）（P>0.05）.2.Clinical efficacy:The total effective rate of the treatment group and the control group was86.66%and 73.33%,respectively.The treatment group was better than the control group,and the difference was statistically significant（P<0.05）.3.TCM syndrome score and CAT score:Before treatment,there was no statistical significance in TCM syndrome scores and CAT scores between the two groups（all P>0.05）.After treatment,TCM syndrome score and CAT score of 2 groups were significantly decreased compared with before,the difference was statistically significant（all P<0.05）,and the treatment group was better than the control group,the difference was statistically significant（all P<0.05）.4.White blood cell count,CRP:Before treatment,there were no significant differences in WBC and CRP between 2 groups（all P>0.05）.After treatment,WBC and CRP in 2 groups were significantly decreased compared with before treatment,the difference was statistically significant（P<0.05）,and the treatment group was better than the control group,the difference was statistically significant（P<0.05）.5.Arterial blood gas analysis of Pa CO₂and Pa O₂:Before treatment,there was no significant difference in Pa CO2 and Pa O2 in arterial blood gas analysis between 2 groups（all P>0.05）.After treatment,Pa CO₂in 2 groups was significantly decreased compared with before treatment,the difference was statistically significant（P<0.05）;after treatment,Pa O₂in 2 groups was significantly increased compared with before treatment,the difference was statistically significant（P<0.05）;There was no statistically significant difference between the two groups in decreasing Pa CO₂level after treatment（P>0.05）,while the treatment group with increasing Pa O₂level was better than the control group,with no statistically significant difference（P<0.05）.Conclusion:Modified Sanzi Yangqin Decoction combined with acupoint application in the treatment of chronic obstructive pulmonary disease patients with phlegm-dampness blocking lung syndrome has good clinical efficacy,can significantly relieve clinical symptoms of patients,reduce abnormal inflammation indicators,improve hypoxemia,and has safety.