| Objective:This research group plans to use the Modifide Yizi Decoction enema proposed by the tutor Professor Wang Zaijian,a new treatment of internal hemorrhoids combined with traditional Chinese and western medicine combined with sclerotherapy under endoscope;Select patients with good indications and randomly divide them into groups:the test group of Modifide Yizi decoction enema combined with sclerosing agent injection and the control group of simple sclerosing agent injection,evaluation of curative effect by hemorrhoid symptom score;To evaluate the effect of modified Yizi decoction retention enema after endoscopic internal hemorrhoid sclerotherapy,I hope to leverage the characteristics of traditional Chinese medicine,start a new treatment of internal hemorrhoids combined with traditional Chinese and western medicine,and promote the scope of application of endoscopy.Methods:1.100 patients with grade Ⅰ to Ⅲ internal hemorrhoids and hematochezia were included in this study,all patients are from the digestive department ward of JD Yumei Integrated Traditional Chinese and Western Medicine Nephropathy Hospital,the eligible patients fill in the general information,explain the test process to the patients,and fill in the informed consent form,then,the method of random number table was used to divide the two groups into two groups:the test group and the control group.2.The test group was treated with modified Yizi decoction enema combined with sclerosing agent injection for internal hemorrhoids,while the control group was treated with sclerosing agent injection for internal hemorrhoids,observe the length of stay,symptom score(blood in stool,anal distension and discomfort,pain)and curative effect of the two groups of patients before and after treatment Tumor Necrosis Factor-α(TNF-α)、Interleukin-10(IL-10)and interleukin-17(IL-17)levels,three months after the treatment,keep in touch with the subjects,track the treatment and conduct statistical analysis.Results:In this study,100 patients with grade Ⅰ to Ⅲ internal hemorrhoids and hematochezia met the requirements,and 100 patients were finally completed,including 50 patients in the test group and 50 patients in the control group.There is no statistical difference between the two groups in general data(P>0.05).1.Total effective rate of treatment:the overall effective rates of the test group and the control group were 94%and 78%respectively.According to the statistical test,the treatment results of the test group were better than those of the control group(P<0.05).2.Comparison of hospitalization days:there was statistical difference between the two groups before and after treatment(P<0.05).There was no difference between the two groups before treatment(P<0.05).There was statistical significance between the two groups after treatment(P<0.05).It shows that both the test group and the control group can effectively treatⅠ-Ⅲ degree internal hemorrhoids with hematochezia,and the treatment effect of the test group is better than that of the control group.3.Symptom score comparison:before the patients received treatment,there was no statistical significance in the single symptom score of the two groups of patients(P>0.05),and the single symptom score of the two groups of patients was comparable,after receiving treatment,the patients in the test group and the control group have statistical differences in each single symptom between the two groups(P<0.001),which shows that the two treatment schemes can achieve significant clinical effects.After receiving standardized treatment,there was a statistical difference(P<0.05)between the two groups of patients in terms of discomfort,pain,and bloody stools with single symptom compared to the control group.Therefore,it can be seen that the treatment plan of the experimental group has better efficacy in improving discomfort,pain,and bloody stools with anal prolapse than the control group.4.Comparison of inflammatory factors:before treatment,there was no statistical difference in inflammatory factors between the two groups(P>0.05),and the two groups were comparable.After treatment,within group comparison,TNF-α、the scores of IL-17 patients in both groups showed a significant decrease compared to before treatment(P<0.01),and the TNF of the experimental group was compared between TNF-α、the decrease in IL-17 was higher than that in the control group(P<0.01);The scores of IL-10 patients in both groups increased compared to before treatment(P<0.01),and compared between groups,the IL-10 levels in the experimental group were higher than those in the control group(P<0.01),From this,it can be seen that Jiajian Yizi Tang directly contacts the inflammatory parts of the body through enema,and acts on IL-17,IL-10,and TNF-α wait for inflammatory cytokines to exert anti-inflammatory effects and alleviate symptoms.5.Comparison of recurrence rates:three months after treatment,the two groups were followed up.There were 2 cases of recurrence in the test group,accounting for 4%,and 4 cases of recurrence in the control group,accounting for 8%.Through the chi-square test,P>0.05.There was no statistical difference between the two groups of patients,and the recurrence rate was comparable between the experimental group and the control group.Conclusion:The treatment of internal hemorrhoids by adding or subtracting Yizi decoction enema combined with endoscopic sclerotherapy,giving full play to the characteristics of traditional Chinese medicine,promoting and expanding the scope of endoscopic adaptation,reducing complications,alleviating the pain of patients,and exploring a new method of combining traditional Chinese and western medicine for the treatment of internal hemorrhoids,which is worthy of promotion and exploration. |
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