| Myopia has become a major public health problem.In the past few decades,the prevalence of myopia has increased,and the risk of blindness has also increased.Myopia is caused by environmental and genetic risk factors in common,there are a lot of myopia management methods and means of prevention and control,pay attention to early detection or prevention,and combined with the other effective therapeutic intervention,to limit the development of myopia.Under the guidance of the thought of "preventive treatment for disease" of traditional Chinese medicine,the application of traditional Chinese medicine characteristic diagnosis and treatment technology to intervene different stages of myopia can prevent the occurrence of myopia,control the development of myopia,and prevent and treat the complications caused by pathological myopia.The cause and pathogenesis of myopia for the heart Yang qi is insufficient,blood transport is weak,the eye blood loss.In modern medicine,myopia is considered to be ischemia and hypoxia caused by shallow retinal microcirculation disorders,resulting in poor perfusion of the choroid,resulting in scleral ischemia and hypoxia,affecting scleral tissue remodeling and causing elongation of the axis of the eye.The method of supplementing Yiqiyangxin,Dingzhiyizhi,strengthen the function of the main blood vessels of the heart,promote the blood circulation of the eye,and help improve the eye ischemia and hypoxia,so it can be used to prevent and control myopia.Objective:This project explores the clinical efficacy of Buxinyiqi method in preventing and controlling myopia in adolescents,and evaluates the role of Buxinyiqi method in preventing and delaying the progression of low myopia in children and adolescents.So as to provide safe and effective treatment methods for clinical practice,and provide clinical basis for the oral administration of traditional Chinese medicine of Buxinyiqi method.Methods:A total of 52 children and adolescents(104 eyes)with low myopia were selected from the ophthalmology clinic of Beijing Hospital of Traditional Chinese Medicine,Capital Medical University.The subjects who met the inclusion criteria were randomly divided into treatment group and control group.In the treatment group,27 cases(54 eyes)were treated with oral Chinese medicine,optometry and glasses,and health education.In control group,25 cases(50 eyes)were given optometry and glasses plus health education.The myopia control rate,spherical equivalent,uncorrected visual acuity,axial length and TCM syndrome score were evaluated before and after treatment.Conclusions were drawn after statistical analysis of the collected data.Results:(1)Before treatment,there were no significant differences in age,gender,intraocular pressure,uncorrected visual acuity,spherical equivalent,axial length,corneal curvature K1,corneal curvature K2,accommodation amplitude,and TCM syndrome score between the two groups(P>0.05).(2)Myopia control rate:At 24 weeks,myopia progression was controlled in 36 eyes in the treatment group(66.67%),and in 22 eyes in the control group(44.00%).The myopia control rate in the treatment group was higher than that in the control group,with statistical significance(X2=5.41,P=0.02).(3)Uncorrected visual acuity:At 24 weeks,the logMAR visual acuity of the treatment group(0.47±0.20)was lower than that of the control group(0.56±0.21),and the difference was statistically significant(Z=-2.41,P=0.02).(4)Spherical equivalent:At 24 weeks,the mean spherical equivalent of the treatment group(-1.88±0.68)was lower than that of the control group(-2.30±0.69),and the difference was statistically significant(t=3.04,P=0.00).The equivalent spherical progression in the treatment group(-0.18±0.32)was lower than that in the control group(-0.32±0.32),and the difference was statistically significant(Z=-2.25,P=0.03).(5)Axial length:At 24 weeks,there was no significant difference in axial length between the two groups(P>0.05).The progress of axial length in treatment group(0.09±0.15)was lower than that in control group(0.15±0.14),and the difference was statistically significant(t=-2.41,P=0.02).(6)Corneal curvature K1,K2 and adjustment amplitude:At 24 weeks,there was no statistical significance in K1,K2 and adjustment amplitude between the two groups(P>0.05).The adjustment amplitude difference between the two groups was calculated,and the adjustment amplitude of both groups was higher than before,but the difference was not statistically significant(P>0.05).(7)TCM syndrome score:At 24 weeks,the TCM syndrome score of the treatment group(1.78±1.50)was lower than that of the control group(6.56±1.87),the difference was statistically significant(Z=-3.29,P=0.00).Compared with the treatment group,the TCM syndrome score at 24 weeks(1.78±1.50)was lower than that at 0 weeks(5.54±2.96),and the difference was statistically significant(Z=-4.12,P=0.00).Conclusion:(1)Buxinyiqi traditional Chinese medicine combined with optometry and health education can effectively control the progression of myopia in children and adolescents with low myopia,and the effective rate and control rate are higher than those in the control group.(2)Buxinyiqi therapy can effectively delay the progression of uncorrected visual acuity,spherical equivalent and axial length in children and adolescents with low myopia,and the effect has a certain continuity.(3)Buxinyiqi therapy can improve the accommodative amplitude of children and adolescents with low myopia.(4)The standardized operation of "health education content+full correction lens" has a certain positive effect on the prevention and control of children and adolescents with low myopia.(5)The Buxingyiqi method can obviously improve the Xinyangbuzu symptoms in TCM.(6)During the study period,no adverse reactions were found and no abnormal safety indicators were found in the oral Chinese medicine of Buxinyiqi method,indicating that the oral Chinese medicine of Buxinyiqi method has good safety. |
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