| Objective: This study evaluated the clinical effect of Jiawei Pipa decoction combined with umbilical acupuncture on acne with gastrointestinal damp heat syndrome by comparing Jiawei Pipa Decoction with umbilical acupuncture in the treatment of acne with gastrointestinal damp heat syndrome.Materials and Methods: 60 cases of gastrointestinal damp heat acne treated in the outpatient department of Dermatology of our hospital from December 2020 to November 2021 were collected and analyzed by spss26.0 software generated 60 randomly assigned card numbers,and 60 patients were randomly divided into observation group and control group.Both groups of patients took orally traditional Chinese medicine decoction(tutor’s self-made "modified loquat Decoction"),recombinant bovine basic fibroblast growth factor(trade name: beifuxin,approval number: Guoyao Zhunzi: s20040001)and chloramphenicol tincture(in-hospital preparation of the Affiliated Hospital of Liaoning University of traditional Chinese medicine,the main components are chloramphenicol,alcohol,etc.).The observation group was treated with umbilical acupuncture,mainly acupuncture "three needles for strengthening the spleen"(Zhen position,Li position and Kun position)and Kan position,and the needles were kept for 6-8 hours every other day.Two weeks as a course of treatment,three consecutive courses of treatment.The TCM syndrome scores,gags and CADI scores before and after treatment were recorded in detail and compared.Finally,Excel(WPS version)was used to input the medical record information and record the scale scores,and spss26.0 was used for statistical analysis of various data,using chi square test,independent sample t-test,paired sample t-test and so on,P < 0.05 has statistical significance,So as to obtain the clinical efficacy and safety of Jiawei Pipa decoction combined with umbilical acupuncture in the treatment of acne with gastrointestinal damp heat syndrome.Results:1.The baseline data of the two groups,such as age(year),course of disease(year)and gender,were tested by independent sample t-test,rank sum test and chi square test:(1)the age of the observation group was 24.23 ± 4.493 and the age of the control group was 23.77 ± 4.368;(2)The course of disease was 3.233 ± 2.797 in the observation group and 3.000 ± 2.319 in the control group;(3)There were 11 males and 19 females in the treatment group and 13 males and 17 females in the control group.After statistical test,the P values of the three groups were greater than0.05,the difference was not statistically significant,and the correlation comparison was feasible.2.The GAGS score,CADI score and TCM syndrome score of the two groups before treatment were tested by independent sample t-test.(1)the GAGS score of the observation group before treatment was 22.13 ± 5.015 and that of the control group was 22.63 ± 5.143;(2)The CADI score before treatment was 8.97 ± 2.206 in the observation group and 8.40 ± 2.943 in the control group;(3)The TCM syndrome score of the observation group before treatment was 10.47 ± 1.737 and that of the control group was 10.43 ± 1.612.The P values of the independent sample t-test results of the three groups were greater than 0.05,the difference was not statistically significant,and the correlation comparison was feasible.3.Rank sum test was performed on the acne grade of the two groups before treatment.In the observation group,there were 7 cases of grade I acne(23%),16 cases of grade II acne(67%)and 7 cases of grade III acne(23%);In the control group,there were 6cases of grade I(20%),20 cases of grade II(54%),and 4 cases of grade III(13%).The results of rank sum test: Z =-0.388,P = 0.698 > 0.05,the difference was not statistically significant,and the correlation comparison was feasible.After 3 courses of treatment,the GAGS score,CADI score and TCM syndrome score of the treatment group were 3.67 ± 3.818,1.37 ± 0.669 and 2.93 ± 1.617 respectively;The GAGS score,CADI score and TCM symptom score of the control group were 6.27± 3.503,2.53 ± 1.042 and 3.30 ± 1.236 respectively.The GAGS score,CADI score and TCM symptom score of the two groups were compared by paired sample t-test.The P values were < 0.001,indicating that the two groups of patients improved after different treatment,and the difference was statistically significant.4.After three courses of treatment,the GAGS score,CADI score and TCM syndrome score of the observation group were 3.67 ± 3.818,1.37 ± 0.669 and2.93 ± 1.617 respectively;The GAGS score,CADI score and TCM syndrome score of the control group were 6.27 ± 3.503,2.53 ± 1.042 and 3.30 ± 1.236 respectively.The gags score,CADI score and TCM syndrome score of the two groups were compared within the group by paired sample t-test.The P values were equal to0.000 < 0.001,indicating that the two groups of patients improved after different treatment,and the difference was statistically significant.5.Compare the scores of each observation table between the two groups after treatment.(1)the scores of GAGs and CADI do not meet the normality,and the rank sum test is used.Comparison between gags groups: Z =-3.730,P = 0.000 < 0.001;Comparison between CADI groups: Z =-4.455,P = 0.000 < 0.001;(2)TCM syndrome score meets the normality,using independent sample t-test,t = 2.129,P =0.037 < 0.005.The scores of the treatment group decreased more significantly,and the difference was statistically significant.6.After the course of treatment,the grade distribution of acne in the observation group: clinical recovery in 2 cases(7%),grade I in 27 cases(90%),grade II in 1 case(3%),and grade III in 0 cases(0%);In the control group,there were 0 cases(0%),23cases(77%)in grade I,6 cases(20%)in grade II and 1 case(3%)in grade III.The rank sum test was performed in the two groups,Z =-2.058,P = 0.040 < 0.05,the difference was statistically significant.7.After the course of treatment,the total effective rate of skin lesions in the observation group was 93.3%,which was better than 83.3% in the control group(using rank sum test,Z =-2.233,P = 0.026).The difference was statistically significant.8.After the course of treatment,the total effective rate of TCM syndrome curative effect in the observation group was 90%,which was better than that in the control group by 80%(using rank sum test,Z =-2.195,P = 0.028).The difference was statistically significant.9.Follow up results: there was no recurrence in both groups after 1 month follow-up;The recurrence rate of skin lesions in the observation group was 0 and that in the treatment group was 16%(P < 0.05).The recurrence rate of TCM syndrome in the observation group was 7% and that in the control group was 12.5%(P > 0.05).Conclusion :1.Gastrointestinal damp heat acne is common in middle-aged and young people;2.The curative effect of modified Pipa decoction combined with umbilical acupuncture in the treatment of acne with gastrointestinal damp heat syndrome is better than that of traditional Chinese medicine decoction group,with low recurrence rate and significant long-term effect.3.In the process of umbilical acupuncture treatment,the patient had no adverse reactions,and umbilical acupuncture therapy was safe and effective. |
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