Study On The Medication Rules Of Professor Wang Fengrong In Treating Anxiety After PCI Of Coronary Heart Diseas

Objective: In this paper,through retrospective study,data mining technology was used to explore professor Wang Fengrong’s diagnosis and treatment experience and medication rule of anxiety state after percutaneous coronary intervention for coronary heart disease.Materials and methods: Medical records and prescriptions of patients with anxiety after PCI treated by Professor Wang in the First Department of Cardiology and TCM Clinic of Liaoning University of Traditional Chinese Medicine Affiliated Hospital from November2019 to November 2021 were collected.WPS Office Excel was used to establish a database of the basic information involved in medical cases and prescription drugs for the first diagnosis.SPSS Statistics 25 and SPSS Molder14.1 were used to analyze frequency,association and cluster.Statistical analysis was conducted on the included prescriptions to explore the rule of prescription medication,find potential combinations and new prescriptions,and discuss the medication rule and academic characteristics of professors in treating anxiety state after PCI.Results:1.According to the analysis of 119 patients included in this study,the incidence of coronary heart disease with anxiety state after PCI was higher in males than in females,and the incidence was concentrated in 61-70 years old.In this study,the incidence rate of patients with liver qi stagnation syndrome,blood stasis syndrome and deficiency of heart and spleen syndrome is relatively high.2.According to the inclusion and exclusion criteria,the collected cases of coronary heart disease with anxiety state after PCI were counted.A total of 119 TCM prescriptions were included,including 136 TCM prescriptions,and the total frequency of drug use was 2059.According to the drug efficacy,it was divided into 16 categories,and the drugs with high frequency of use were tonifying deficiency drugs,promoting blood circulation and removing stasis drugs,tranquilizing drugs,invigorating water and permeating humidity drugs,regulating qi drugs;The high frequency TCM included prepared glycyrrhiza root(115 times),salvia miltiorrhiza root(102 times),turmeric root(88 times),paeony root(81 times),Atractylodes atractylodes macrocephala(75 times),etc.The use frequency of the four qi was776 times for cold,751 times for warm and 499 times for flat.The highest frequency of medicinal taste was sweet taste 1217 times,bitter taste 1116 times and spicy taste 552 times.The frequency of the application of traditional Chinese medicine was 1108 times for liver meridian,1041 times for heart meridian and 945 times for spleen meridian.3.The statistical software was used to analyze the association rules of 136 Traditional Chinese medicines(excluding prepared glycyrrhiza glycyrrhiza).The support degree was set to 45% and the minimum rule confidence was set to 85%.Cluster analysis was carried out for the top 30 high-frequency Chinese medicines,and the optimal cluster number was 4,and the cluster analysis results obtained four drug formulations.The first group: Polygonum cuspidatum,Fructus auriculata,Rhubarb,Alisma rhizoma,Salvia miltiorrhiza,Paeonia alba,prepared glycyrrhiza,Aurantium trifoliata,Scutellaria baicalensis,Pinellia pinellia,Bupleurum,Panax notoginseng,Turmeric gold;The second group: lily,rehmannia glutinosa;The third group of prescriptions: radix paeoniae root,Earthworm,Corydalis corydalis,ligusticum chuanxiong,Safflower,peach kernel,Atractylodes macrocephala,Poria cocos,Astragalus membranaceus,Angelica;The fourth group: Polygala,Cypress seed,Radix pseudostellariae,ziziphus jujube seed,Rhizome.Conclusion:1.The pathogenesis of coronary heart disease after PCI accompanied by anxiety state was mixed with deficiency and reality.Most patients who came to see a doctor were mainly liver qi stagnation and blood stasis,accompanied by phlegm,heat,Yin deficiency and other syndromes;Professor Wang’s basic treatment concept for coronary heart disease accompanied by anxiety after PCI is to focus on soothing the liver and relieving depression,promoting blood circulation and removing blood stasis,nourishing the heart and calming the mind,supplementing with invigorating qi and invigorating spleen,regulating qi and eliminating phlegm,etc.2.In the treatment of coronary heart disease associated with anxiety after PCI,Professor Wang Fengrong mostly used tonic drugs,blood-activating and stasis-removing drugs,and sedative drugs,with variable efficacy;The medicinal properties are mainly cold,warm and flat,and the medicinal taste is mainly sweet,bitter and spicy.Drug use refers to the viscera,especially the liver,heart and spleen.3.Professor Wang’s core drugs for the treatment of this disease are prepared glycyrrhiza,salvia miltiorrhiza,turmeric,paeonia alba,Atractylodes atractylodes,Astragalus membranaceus,Panax notoginseng,Poria cocos,etc.Common drugs for atractylodes atractylodes,Poria cocos,salvia miltiorrhiza,paeony,safflower,peach kernel,salvia miltiorrhiza,panax notoginseng;Through cluster analysis,four types of prescriptions were obtained for the treatment of anxiety state after PCI for coronary heart disease,which were composed of Dacaihu Decoction,Baihe Dihuang Decoction,Buyang Huanwu Decoction and Anzhiningshen drugs respectively.