Objective:By studying the therapeutic effect of Liumo Zengye Decoction on opioid-related constipation(Qi stagnation and Jin deficiency syndrome)in patients with cancer pain,the clinical efficacy of Six grinding liquid soup on oral opioid-related constipation in patients with cancer pain was discussed,as well as the related symptoms and whether it affected the quality of life or pain score.So as to provide more objective basis for traditional Chinese medicine treatment of opioid-related constipation,and provides clinical experience accumulation for the effective program of opiate-related constipation(OIC).Methods:From February 2021 to December 2021 in Changde,the first hospital of TCM oncology outpatient and the inpatient patients select met inclusion and exclusion criteria for oral opioids correlation caused by constipation(OIC)62 cases of patients with pain(Qi stagnation and Jin deficiency syndrome)(During the treatment,there were 2 cases of detachment,including 1 case in the control group and 1 case in the treatment group.A total of 60 cases were finally analyzed statistically),through the completely randomized grouping method is divided into treatment group and control group,30 cases were to six grinding liquid soup and the control group to lactulose oral solution.Those treatment process will be for 2 weeks.The constipation symptom score,TCM syndrome score,constipation quality of life score and pain score were observed after 1 and 2 weeks of medication,and the results were statistically analyzed.Results:1.There was statistically significant comparison between the two groups in terms of gender,age,disease type,oral opioid dosage and KPS score(P>0.05).2.Comparison of scores of constipation symptoms before and after treatment between the two groups:the total scores of constipation symptoms after 1 week and 2 weeks of treatment were compared with those before treatment,and there was significant statistical difference(P<0.01);After 2 weeks of treatment,the treatment group was superior to the control group in reducing the total score of constipation symptoms,with significant statistical difference(P<0.01).There was no statistical difference in the scores of single symptoms of constipation after 1 week,2 weeks and before treatment between 2 groups in terms of "incomplete defecation and anal heave"(P>0.05).There were statistically significant differences in"defecation frequency","defecation effort"," abdominal pain and abdominal distension","time per visit to the toilet(min)" and "fecal characteristics"(P<0.01).One week after treatment,the treatment group was superior to the control group in improving defecation effort,abdominal pain and abdominal distension(P<0.05),and there were no significant differences in other symptoms of constipation,such as toilet time,fecal characteristics and defecation frequency(P>0.05).Two weeks after treatment,the treatment group was superior to the control group in defecation effort,defecation frequency,abdominal pain,abdominal distension and toilet time(P<0.05),but there was no statistical difference in the improvement of fecal traits between the two groups(P>0.05).3.Comparison of TCM syndrome scores between the two groups before and after treatment:there was significant statistical difference in the total TCM syndrome scores between the two groups after 1 week and 2 weeks of treatment and before treatment(P<0.01);After 2 weeks of treatment,the treatment group was superior to the control group in improving TCM syndrome,with statistical difference(P<0.05).The scores of each single syndrome in TCM were compared,and there were significant statistical differences in the scores of each single syndrome in TCM after 1 week,2 weeks and before treatment(P<0.01).One week after treatment,the treatment group was superior to the control group in the improvement of fullness and tightness of chest and hypochondria,abdominal distension and abdominal pain(P<0.05),and there was no statistical difference in the improvement of other TCM syndromes such as depressed mood and dry mouth wanting to drink(P>0.05).Two weeks after treatment,the treatment group was superior to the control group in terms of depressed mood,fullness and tightness of chest and flank,dry mouth,abdominal distension and abdominal pain(P<0.05).4.Comparison of constipation quality of life scores between the two groups before and after treatment:constipation quality of life scores between the two groups after 1 week and 2 weeks of treatment were compared with those before treatment,respectively,and there were significant statistical differences(P<0.01);After 2 weeks of treatment,the quality of life in the treatment group was better than that in the control group,with statistical difference(P<0.05).5.Comparison of pain scores between the two groups before and after treatment:there was statistical difference in pain scores between the two groups after 1 week of treatment and before treatment(P<0.05).After 2 weeks of treatment,there was significant statistical difference in pain scores between 2 groups(P<0.01).The results showed that both groups had analgesic effect after 1 week of opioid treatment,and significant therapeutic effect after 2 weeks of treatment.There was no significant difference in pain scores between the treatment group and the control group at 1 week and 2 weeks after treatment(P>0.05).It indicated that there was no significant difference in treatment effect between the two groups after 1 and 2 weeks of opioid use.The results of intra-group comparison suggest that the analgesic effects of opioids in the two groups are consistent,and the analgesic effects achieved by opioids in the two groups are comparable.6.No obvious adverse reactions were observed in the studies on opioid-related constipation(Qi stagnation and Jin deficiency syndrome)of cancer pain patients in the two groups,indicating that the two treatment schemes are relatively safe.Conclusion:1.Six Grinding Liquid Soup can improve opioid-related constipation symptoms of cancer pain patients and improve their life quality of constipation.2.Six grinding liquid soup was better than lactulose oral solution in improving constipation associated symptoms(such as defecation frequency,defecation frequency,defecation effort,abdominal pain abdominal distension,etc.)and Qi stagnation and Jin deficiency syndrome(Poor mood,chest and hypochondriac full stuffy,dry mouth to drink,abdominal distension abdominal pain). |