Clinical Research Of Acupuncture Treatment Of Acute Gastrointestinal Injury In Sepsis

Objective: Acupuncture at Shangwan,Zhongwan,Xiawan,Qihai,Guanyuan,bilateral Tianshu,Daheng,Zusanli,Shangjuxu,Xiajuxu points was performed for patients with sepsis with acute gastrointestinal injury to explore the clinical effect and mechanism of acupuncture.This study will provide a new method and further theoretical exploration for sepsis with acute gastrointestinal injury.Methods:Seventy patients who met the diagnosis of acute gastrointestinal injury of sepsis and the diagnosis of Traditional Chinese medicine selected in intensive care unit and Emergency Medicine Department of Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated to Shanghai University of Traditional Chinese Medicine.They were randomly divided into two groups: control group(n=35)and experimental group(n=35).The control group used conventional treatment methods;The experimental group combined acupuncture therapy on the basis of control group therapy.The experimental group was given acupuncture at Shangwan,Zhongwan,Xiawan,Qihai,Guanyuan,bilateral Zusanli,Shangjuxu,Xiajuxu and electro-acupuncture at bilateral Tianshu,Daheng once a day,30 min each time,and the treatment cycle is 7 days.We evaluated the change of APACHEⅡscore,SOFA score,AGI grading,Gastrointestinal Symptom Rating Scale,TCM syndrome differentiation score of critically ill abdominal distension and detected the change of gastrointestinal index(bowel sounds,intra-abdominal pressure),inflammation index(PCT,IL-6,IL-10),immune index(CD3+,CD19+,CD56+,CD3+CD4+,CD3+CD8+,CD4+/CD8+),intestinal barrier index(I-FABP,D-la,DAO).Results:1.Before treatment,there were no significant differences in the gender,age,APACHEⅡscore,SOFA score,AGI grading,Gastrointestinal Symptom Rating Scale,TCM syndrome differentiation score of critically ill abdominal distension,bowel sounds,intra-abdominalpressure,PCT,IL-6,IL-10,CD3+,CD19+,CD56+,CD3+CD4+,CD3+CD8+,CD4+/CD8+,I-FABP,D-la,DAO between the experimental group and the control group(P>0.05).The baseline is the same.These statistical was comparable.2.TCM syndrome integral and effective rate: After treatment,the total effective rate of the experimental group was 77.1%,and the total effective rate of the control group was54.3%.The effective rate difference of the two groups after treatment was significant(p<0.05).The TCM syndrome differentiation score of critically ill abdominal distension of the experimental group and the control group after treatment were significantly different(P<0.01),and the comparison between the two groups showed statistical differences(P<0.05).3.Comparison before and aftert reatment in the experimental group: APACHEⅡscore,SOFA score,AGI grading,GSRS score,IAP,bowel sounds,CD3+,CD56+,CD3+CD4+,CD4+/CD8+,D-la after treatment in the experimental group were significantly different than before treatment(P<0.01);PCT,IL-6,IL-10,CD19+,CD3+CD8+,I-FABP,DAO were statistical differences than before treatment(P<0.05).4.Comparison before and after treatment in the control group: APACHE Ⅱ score,AGIgrading,GSRS score,IAP,bowel sounds,DAO after treatment in the control group were significantly different than before treatment(P<0.01);SOFA score,PCT,IL-6,IL-10,CD3+,CD19+,CD56+,CD3+CD4+,CD3+CD8+,CD4+/CD8+,I-FABP,D-la were not statistical difference than before treatment(P>0.05).5.Comparison between the test group and the control group after treatment and the difference: APACHE Ⅱscore,SOFA score,GSRS score,IAP,bowel sounds,CD19+,CD4+/CD8+,DAO were significantly different(P<0.01);AGI grading,IL-6,CD3+,CD56+,CD3+CD8+,D-la were statistical differences(P<0.05);PCT,IL-10,CD3+CD4+,I-FABP were not statistical difference(P>0.05).Conclusion: 1.Acupunctured on related acupoints can significantly improve the TCM syndrome scores and organ scores of patients with acute gastrointestinal injury in sepsis,and improve the gastrointestinal symptoms of patients.2.Acupunctured at related points can regulate the inflammatory factors in patients with acute gastrointestinal injury in sepsis,and regulate the body’s systemic inflammatory response.3.Acupunctured at relevant acupoints can improve the immunity of patients with acute gastrointestinal injury in sepsis,reduce the body’s immunosuppressive state,and regulate the body’s immune function.4.Acupunctured at relevant acupoints can reduce the intestinal barrier damage of patients with acute gastrointestinal injury in sepsis,and regulate the body’s intestinal function.