A Study Of The Effects Of Shibao Decoction On Skeletal Muscle Index Of Patients With Male Climacteric Syndrome With Kidney Essence Deficiency

Objective To explore the clinical therapeutic effects of Shibao Decoction and its effect on the skeletal muscle index(SMI)of middle-aged and elderly males.Methods Sixty patients who were admitted to the andrology outpatient clinic of Yinchuan Traditional Chinese Medicine Hospital Affiliated to Ningxia Medical University and diagnosed with male climacteric syndrome differentiated as kidney essence deficiency type from January 2022 to October 2022 were randomly assigned to the treatment group(N=30)or control group(N=30).The treatment group was treated with Shibao Decoction for12 weeks,100 ml taken warm after meal twice a day.The control group was treated orally with testosterone undecanoate capsules for 12 weeks,160 mg a day taken with warm water as two 80 mg doses in the morning and evening for the first week,120 mg a day taken with warm water as one 80 mg dose in the morning and one 40 mg dose in the evening for the next week,and maintained at 80 mg a day taken with warm water as two 40 mg doses in the morning and evening for the rest 10 weeks.All other medications were discontinued during treatment.PADAM symptoms score and TCM symptoms score were recorded,and TT,SHBG,FT,BMI,SMI,and ASMI were detected for each patient pre-treatment and at 6 weeks and 12 weeks of treatment.Stata/MP 17.0 was used for the statistical analysis of the data.Results 1.At 6 weeks of treatment,PADAM scores for each item had decreased in both groups,all with statistically significant differences from those of pre-treatment(P<0.05);at 6 weeks of treatment,there were no statistically significant differences between the two groups in vascular+physical or mental-psychological scores(P>0.05),and the sexual function score was better in the treatment group than in the control group(P<0.05);at 6 weeks of treatment,the effective rate in terms of symptoms score was 40% in the treatment group and43.3% in the control group,without statistically significant difference between the two groups(P>0.05).2.At 6 weeks of treatment,TCM symptoms score had decreased in both groups,both with statistically significant differences from those of pre-treatment(P<0.05).At 6 weeks of treatment,there was no statistically significant difference between the two groups in the score(P>0.05);at 6 weeks of treatment,the effective rate in terms of TCM symptoms score was46.6% in the treatment group and 43.3% in the control group,without statistically significant difference between the two groups(P>0.05).3.At 6 weeks of treatment,TT and FT had increased in both groups,all with statistically significant differences from those of pre-treatment(P<0.05),and there was no significant decrease in SHBG(P>0.05);at 6 weeks of treatment,there were no statistically significant differences between the two groups in TT,FT,or SHBG(P>0.05).4.At 6 weeks of treatment,SMI and ASMI had increased in both groups,all with statistically significant differences from those of pre-treatment(P<0.05);BMI had decreased in the control group,with a statistically significant difference(P<0.05),and had not changed significantly in the treatment group(P>0.05);at 6 weeks of treatment,there were no statistically significant differences between the two groups in BMI,SMI,or ASMI(P>0.05).5.At 12 weeks of treatment,PADAM scores for each item and TCM symptoms score had decreased in both groups,all with statistically significant differences from those of pre-treatment(P<0.05);at 12 weeks of treatment,there were no statistically significant differences between the two groups in PADAM scores or TCM symptoms score(P>0.05);at12 weeks of treatment,the effective rate in terms of symptoms score was 73.3% in the treatment group and 66.7% in the control group,without statistically significant difference between the two groups(P>0.05).The effective rate in terms of TCM symptoms score was86.6% in the treatment group and 76.6% in the control group,without a statistically significant difference between the two groups(P>0.05).6.At 12 weeks of treatment,TT and FT had increased in both groups,all with statistically significant differences from those of pre-treatment(P<0.05);SHBG had decreased in the control group,with a statistically significant difference(P<0.05),and had not changed significantly in the treatment group(P>0.05);at 12 weeks of treatment,there were no statistically significant differences between the two groups in TT,FT,or SHBG(P>0.05).7.At 12 weeks of treatment,SMI and ASMI had increased in both groups,all with statistically significant differences from those of pre-treatment(P<0.05);BMI had decreased in the control group,with a statistically significant difference(P<0.05),and had not changed significantly in the treatment group(P>0.05);at 12 weeks of treatment,there were no statistically significant differences between the two groups in BMI,SMI,or ASMI(P>0.05).Conclusion Shibao Decoction can effectively reduce PADAM symptom score and TCM symptom score,improve discomfort symptoms,increase sex hormone level and skeletal muscle volume of patients.Shibao Decoction is generally comparable with testosterone undecanoate in the therapeutic effects.No adverse drug reactions were reported in either group,indicating favorable safety profile of the investigational products.