Clinical Research Of Erxian Soup On The Treatment Of The Male Climacteric Syndrome Of Nephrasthenia Syndrome

Background: male climacteric syndrome is a middle-aged men from the elderly in the corresponding period of clinical symptoms and signs of a syndrome, the clinical manifestations of neurological disorders, depression, insomnia, irritability, decreased sexual desire, erectile dysfunction, loss of hair And abdominal obesity. Some scholars believe that after the middle-aged men from the androgen levels decreased gradually, from the above symptoms, such as in the old men of the lack of androgen syndrome (PADAM), accompanied by decline in serum testosterone, therefore, the clinical use of testosterone as a supplementary treatment Is a commonly used method, but long-term use of testosterone on a number of body systems and organs have an impact], some clinicians on the use of different drug treatment. Chinese medicine is China's treasures, there are several thousand years of history, after thousands of years of clinical practice of Chinese medicine for the discovery of smaller drug side effects, The TCM treatment, with modern medical tests failed to detect the apparent anomaly indicators. From May 2005-2008 March we used Erxian-treatment of male climacteric syndrome Achieve better results.Objective: To evaluate the therapeutic efficacy of Erxian Soup in the treatment of male climacteric syndrome of deficiency syndrome of both YIN and YANG.Methods: 127 patients who suffered male climacteric syndrome and were deficiency syndrome of both YIN and YANG between 40 and 64 old years were divided into two groups at randomly. First group (n=52) were giving testosterone undecanoate (TU) for 12 weeks, the second group (n=75) were giving Erxian Soup for 12 weeks too. All patients took examinations , such as alanine aminotransferase (ALT), serum creatinine ( SC ) , free testosterone(F-T), Bultrasonograph of prostate gland in prior treatment and post-treatment. To evaluate the measuring scale value about TU and Erxian Soup in the treatment of male climacteric syndrome in accordance with《clinical research guidance principle on new drug of the traditional Chinese medicine》published by China. We undertook statistical analysis using software of SPSS12.0.Result : F-T in blood increased obviously in TU treated patients for 12 weeks (P<0.01), while no obviously changed in TCM treated patients(P>0.05). The symptoms of male climacteric syndrome all improved obviously after using not only TU group but also Erxian soup group(P<0.01). The symptoms of vasomotion, spirit, mind or sexual function were significant difference between prior-treatment and post-treatment in two groups (P<0.01). Value of symptom and physical sign correlated deficiency syndrome of both YIN and YANG was significant difference between prior-treatment and post-treatment in Erxian Soup .We evaluated effect according to measuring scale of male climacteric syndrome and arrived at consequence: Ratio of invalid, utility, excellence, clinical curing were 34. 6%, 42. 3%, 17. 3%, 5. 7% in TU group. Ratio of invalid, utility, excellence, clinical curing were 37.3%, 36.0%, 14.0%, 2.7% in Erxian Soup group. There were no significant difference in two groups (P>0. 05).Conclusion: Consequence of syndrome' improvement is no significant difference between TU and Erxian in the treatment of male climacteric syndrome, the effect of Erxian soup on the treatment of the male climacteric syndrome is to increase Qi and invigorate the kidney and make yinyang balanced, especially for adult male who suffered the disease of benign prostatic hyperplasia.