Clinical Study Of Continuous Blood Purification In The Treatment Of Severe Acute Pancreatitis

Objectives: To observe the clinical efficacy of continuous blood purification(CBP)in the treatment of severe acute pancreatitis(SAP),and to explore the role and clinical application value of CBP technology in the treatment of SAP.Methods: A retrospective cohort study method was used to collect the inpatient data of 131 patients with SAP who were hospitalized in the Second Department of General Surgery of the Affiliated Hospital of Yunnan University from January 2017 to December 2022.According to the inclusion and exclusion criteria,60 patients eligible for the study were screened out.For example,patients were divided into continuous blood purification treatment group(abbreviated as observation group)and discontinuous blood purification treatment group(abbreviated as control group)according to whether they received CBP treatment.The control group received routine medical treatment,and the observation group received conventional medical treatment combined with CBP treatment,with 30 patients in each group.The general information,vital signs,acute physiology and chronic health evaluation(APACHEⅡ),laboratory test results,length of hospital stay,prognosis and other clinical data of the two groups of patients were collected.The data were statistically analyzed to evaluate the clinical efficacy of CBP in the treatment of SAP patients.Results:1.General information of patients in the observation group and control group(age,sex,cause of disease),admission vital signs(mean arterial pressure(MAP),respiration(R),body temperature(T),heart rate(P)),admission APACHE Ⅱ Scores were compared between groups,P>0.05,the difference was not statistically significant.2.Liver function of the observation group and the control group before clinical treatment: total bilirubin(Total bilirubin,TBIL),aspartate aminotransferase(Aspartate aminotransferase,AST),alanine aminotransferase(Alanine aminotransferase,ALT);renal function: serum creatinine(Serum creatinine,SCR),blood urea nitrogen(Blood urea nitrogen,BUN);inflammation indicators: white blood cell(White blood cell,WBC),C-reactive protein(C-reactive protein,CRP),Procalcitonin(PCT);electrolyte levels: blood sodium,blood potassium,blood calcium and other laboratory indicators were compared between groups,P>0.05,the difference was not statistically significant.3.Liver function after clinical treatment in the observation group and control group:TBIL,ALT,AST;renal function: SCR,BUN;inflammation indicators: WBC,PCT,CRP;electrolyte levels: blood sodium,blood potassium,blood calcium and other laboratories Indexes were compared between groups,P<0.05,the difference was statistically significant.4.Liver function before and after clinical treatment in the observation group: TBIL,ALT,AST;renal function: SCR,BUN;inflammation indicators: WBC,PCT,CRP;electrolyte levels: blood sodium,blood potassium,blood calcium,etc.Comparing the room indicators within the group,P<0.05,the difference was statistically significant.5.The hospitalization time of patients in the observation group and the control group were compared between the two groups,P<0.05,the difference was statistically significant.6.The prognosis outcome(cured or improved,not cured,death)of the two groups of patients in the observation group and the control group was compared between the two groups.The difference between the two groups was statistically significant,P<0.05,compared with the cured or improved cases;Compared with the unhealed cases in the two groups,P<0.05,the difference was statistically significant;compared with the death cases in the two groups,P>0.05,the difference was not statistically significant.Conclusions: CBP can effectively reduce inflammatory indicators in patients with SAP,protect organ function,maintain internal environment stability,shorten hospital stay,improve prognosis,and have a certain clinical effect.It can be used as an important treatment for SAP.Promote apps.