Retrospective Study Of Risk Factors Of Osteoporotic Fracture And Secondary Fracture In Middle-aged And Elderly People

Objective:To analyze the clinical characteristics of osteoporotic fracture and study the risk factors of secondary fracture in elderly patients with osteoporotic fracture,so as to provide the decision basis for early intervention of osteoporotic fracture,so as to give appropriate intervention measures to reduce the occurrence of secondary fracture.Methods:The clinical data of 305 cases of osteoporosis fracture diagnosed in the Third Affiliated Hospital of Guangzhou Medical University from January 2020 to December 2022 were retrospectively analyzed,and the age,gender,season of onset,fracture site,bone mineral density T-value,and anti-osteoporosis treatment were described.They were then divided into case group and control group according to whether there was a secondary fracture.General data(gender,age,systolic blood pressure,diastolic blood pressure,BMI,season of onset),laboratory indicators(hemoglobin,serum albumin,cholinesterase,blood glucose,creatinine,uric acid,serum potassium),imaging examination(bone density,fracture),disease complications and adverse living habits(hypertension,diabetes,renal insufficiency,cardiovascular disease,neurosurgery disease,eye disease,chronic osteoarthropathy,smoking history,alcohol abuse history)and treatment(fracture treatment,anti-osteoporosis treatment)were compared.SPSS25.0 statistical software was used,Chi-square test and nonparametric test were used to compare the incidence of the two groups of patients,and binary Logistic regression was used to analyze the risk factors of secondary fracture.Results:1,Female patients with ostoporotic fractures were much larger than males,male to female ratio of 1:5.6.The mean age was(76.3±10.4)years,and the distribution ranged from 51 to 100 years.The peak season was spring and summer,and the peak site was vertebral body.The average bone mineral density T value was(-3.31±0.94),and the distribution was between 0.5 and-6.5.2.In terms of drug therapy,the rate of basic treatment(calcium and vitamin D)for osteoporosis was 81.6 %,and the rate of anti-osteoporosis treatment(bisphosphonate,RANKL inhibitor,calcitonin)was 72.5%.In terms of surgical treatment,28.1% of patients chose conservative treatment,with an average length of hospital stay of(9.3±6.3)days,and 71.8% of patients chose surgical treatment,with an average length of hospital stay of(7.9±6.2)days,with a conservative/surgical ratio of 1:2.6.3.Univariate analysis and Chi-square test between case group and control group showed statistically significant differences only in age,BMI,hemoglobin,bone density T value,diabetes mellitus,eye disease,and previous surgical history(P <0.05).4.Logistic regression analysis showed that low BMI,low bone mineral density T-value,combined diabetes and eye disease were independent risk factors for osteoporotic secondary fractures.Conclusion:1.There are more females than males in patients with osteoporotic fractures,and females and elderly patients are the high-risk groups for osteoporotic fractures.The most common season of osteoporosis fracture is spring and summer,and the most common part is spine.The mean bone mineral density T-value was(-3.31±0.94),and the majority of patients were in the range of-2.5 to-2.9.The rates of basic treatment and anti-osteoporosis treatment were 81.6% and 72.5% during hospitalization2.In case-control studies,age,BMI,hemoglobin,T-value bone mineral density,diabetes,eye disease,and previous surgical history may be related factors for osteoporotic secondary fractures.3.Binary Logistic regression analysis of related factors showed that low BMI,low bone mineral density T-value,combined with diabetes and eye disease were independent risk factors for osteoporotic secondary fractures.