FRAX Combined With Serological Markers To Assess The Risk Of Osteoporosis In Elderly T2DM Patients Research

Objective To evaluate the risk of osteoporosis in elderly T2 DM patients using FRAX combined with serological indicators and analyze its correlation.Methods 68 patients with elderly T2 DM who met the inclusion criteria in our hospital（observation group）and 48 healthy people in the same period（control group）were included.The levels of bone mineral density value,in parallel Fracture risk assessment tool was used to calculate the risk of hip fracture and the rate of major osteoporosis,and then the clinical characteristics of T2 DM patients with osteoporosis were analyzed.Results The levels of blood glucose（10.43±3.59）,alkaline phosphatase（127.39±28.43）,calcium（2.05±0.16）and phosphorus（1.15±0.32）in the observation group was significantly higher than that of the control group of blood glucose（5.32±0.62）,alkaline phosphatase(（106.45±38.09）,calcium（2.16±0.26）and phosphorus（0.88±0.13）,and the BMD（-1.87±1.12）was lower than that of the control group of the BMD level（-1.32±1.54）,the difference between the two groups was statistically significant（P < 0.05）.Pearson correlation showed that serum calcium and phosphorus levels were positively correlated with bone mineral density（r=0.379,P < 0.05,r = 0.0474,P < 0.05）,and alkaline phosphatase was negatively correlated with bone mineral density（r-0.523,P < 0.05）.ROC survival curve shows that hip fracture risk（HF）and major osteoporosis（MO）can early predict the future fracture risk of T2 DM patients.Conclusion T2 DM combined with osteoporosis,FRAX fracture risk score combined with serological indicators can accurately screen high osteoporosis diabetic patients,so as to timely intervene and improve the prognosis of the disease.