Correlation Study Of Polycystic Ovary Syndrome And Chronic Endometritis

Objective1.By studying the correlation between polycystic ovary syndrome(PCOS)and chronic endometritis(CE)in infertile patients,we aim to determine whether PCOS patients are more likely to develop chronic endometritis,thereby increasing clinical attention to chronic endometritis in patients with polycystic ovary syndrome,in order to improve the fertility rate and guide diagnosis and treatment of infertile PCOS patients.2.Explore the relationship between polycystic ovary syndrome and chronic endometritis,determine whether polycystic ovary syndrome can exacerbate chronic endometritis,and preliminarily explore the correlation mechanism between the two through the relationship between the two and polyps,providing clinical data for the endometrial condition of patients with polycystic ovary syndrome.Methods1.Retrospective analysis of 392 patients aged 18-40 with polycystic ovary syndrome(PCOS)diagnosed as "infertility" at the Third Affiliated Hospital of Guangzhou Medical University from March 2019 to March 2023,who underwent hysteroscopy.According to the pathological diagnostic criteria of chronic endometritis(CE)in our gynecological outpatient center,there were 212 cases in the polycystic ovary syndrome with chronic endometritis group(PCOS+CE group)and180 cases in the polycystic ovary syndrome without chronic endometritis group(PCOS group).2.A total of 350 patients aged 18-40 who underwent hysteroscopy during the same period due to male infertility were selected as the control group.According to the pathological diagnostic criteria of chronic endometritis(CE)in our gynecological outpatient center,there were 80 cases in the group with chronic endometritis(CE group)and 270 cases in the group without chronic endometritis(non PCOS non CE group).3.Collect general data of four groups of patients(age,years of infertility,parity,BMI,waist to hip ratio,etc.),endocrine and metabolic indicators(AMH,P,E,LH,FSH,SHBG,T,FAI),glucose metabolism indicators(fasting blood glucose,fasting insulin,HOMA-IR),lipid metabolism indicators(TC,TG,UA,HDL,LDL),and collect hysteroscopic images of patients,as well as pathological results after endometrial biopsy under hysteroscopy,Record the number of double positive cells and the presence or absence of polyps.4.Analyze the general information,endocrine indicators,glucose metabolism indicators,lipid metabolism indicators,number of double positive cells,presence or absence of polyps,and endometrial characteristics under hysteroscopy of the above four groups of data.Results1.There was significant difference in CE incidence rate between PCOS and non PCOS patients(P<0.05).2.The levels of LH,E2,T,fasting blood glucose,fasting insulin,cholesterol,triglycerides,uric acid,AMH,HOMA-IR in PCOS patients were significantly higher than those in non PCOS patients(P<0.05).3.The number of double positive cells in the PCOS+CE group was significantly higher than that in the simple CE group(P<0.05).4.There was no significant difference in FSH,LH,E2,P,T,fasting blood glucose,fasting insulin,high-density lipoprotein,low-density lipoprotein,cholesterol,triglyceride,uric acid,AMH,waist hip ratio and HOMA-IR between PCOS+CE group and pure PCOS group(P>0.05).5.There was significant difference in the incidence rate of polyps between PCOS group and non PCOS and non CE group(P<0.05).6.There was a significant difference in the incidence rate of polyps between CE group and non PCOS and non CE group(P<0.05),and there was no significant difference in the incidence rate of polyps among the groups with different numbers of double positive cells(P>0.05).7.There was no significant difference in the incidence rate of polyps between the PCOS+CE group and the PCOS alone group(P>0.05).8.There was a significant difference in the performance of CE under hysteroscopy between PCOS patients and non PCOS patients in simple endometrial congestion(P<0.05).Conclusion1.There is a correlation between polycystic ovary syndrome and chronic endometritis.2.Patients with polycystic ovary syndrome have more severe disorders of sexual hormones,glucose metabolism,and lipid metabolism than those without polycystic ovary syndrome.3.Polycystic ovary syndrome combined with chronic endometritis can exacerbate the severity of chronic endometritis.4.The combination of polycystic ovary syndrome and chronic endometritis does not exacerbate the disorder of sex hormones,glucose metabolism,and lipid metabolism in polycystic ovary syndrome.5.The incidence rate of polyps in patients with polycystic ovary syndrome is higher than that in patients without polycystic ovary syndrome.6.The incidence rate of polyps in patients with chronic endometritis is higher than that in patients without chronic endometritis.The occurrence of polyps is not related to the severity of chronic endometritis.7.There is no significant difference in the incidence rate of polyps between patients with polycystic ovary syndrome and chronic endometritis and patients with simple chronic endometritis.The relationship between the two still needs further exploration.8.Patients with polycystic ovary syndrome exhibit significantly more chronic endometritis under hysteroscopy compared to non polycystic ovary syndrome patients due to simple endometrial congestion.